ReviewThe international journal of biochemistry & cell biology2009
Role of unusual O-glycans in intercellular signaling.
Review in The international journal of biochemistry & cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 71 citations in OpenAlex.
- POFUT1 as a cancer biomarker: insights into its oncogenic mechanisms and clinical relevance.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Aberrant Sialylation in Ovarian Cancer: Orchestrating Progression, Metastasis, and Therapeutic Hurdles.Current medical science · 2025Review
- Review
- Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates.Advances in neurobiology · 2023Article
- Notch signaling pathway: architecture, disease, and therapeutics.Signal transduction and targeted therapy · 2022Review
- Glycans in autophagy, endocytosis and lysosomal functions.Glycoconjugate journal · 2021Review
- Article
- Computational insights into O-glycosylation in a CTLA4 Fc-fusion protein linker and its impact on protein quality attributes.Computational and structural biotechnology journal · 2020Article
- Analysis of Mammalian O-Glycopeptides-We Have Made a Good Start, but There is a Long Way to Go.Molecular & cellular proteomics : MCP · 2018Review
- The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA.Nature chemical biology · 2017Article
- Altered fucosyltransferase expression in the superior temporal gyrus of elderly patients with schizophrenia.Schizophrenia research · 2017Article
- A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2.Nature chemical biology · 2016Article
- Glycosylation in cancer: mechanisms and clinical implications.Nature reviews. Cancer · 2015Review
- Peters plus syndrome mutations disrupt a noncanonical ER quality-control mechanism.Current biology : CB · 2015Article
- Mannose metabolism: more than meets the eye.Biochemical and biophysical research communications · 2014Review
- Novel roles for O-linked glycans in protein folding.Glycoconjugate journal · 2014Article
- Site-specific O-glucosylation of the epidermal growth factor-like (EGF) repeats of notch: efficiency of glycosylation is affected by proper folding and amino acid sequence of individual EGF repeats.The Journal of biological chemistry · 2012Article
- Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation.The EMBO journal · 2012Article
- Vertebrate protein glycosylation: diversity, synthesis and function.Nature reviews. Molecular cell biology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the last two decades, our knowledge of the role of glycans in development and signal transduction has expanded enormously. While most work has focused on the importance of N-linked or mucin-type O-linked glycosylation, recent work has highlighted the importance of several more unusual forms of glycosylation that are the focus of this review. In particular, the ability of O-fucose glycans on the epidermal growth factor-like (EGF) repeats of Notch to modulate signaling places glycosylation alongside phosphorylation as a means to modulate protein-protein interactions and their resultant downstream signals. The recent discovery that O-glucose modification of Notch EGF repeats is also required for Notch function has further expanded the range of glycosylation events capable of modulating Notch signaling. The prominent role of Notch during development and in later cell-fate decisions underscores the importance of these modifications in human biology. The role of glycans in intercellular signaling events is only beginning to be understood and appears ready to expand into new areas with the discovery that thrombospondin type 1 repeats are also modified with O-fucose glycans. Finally, a rare form of glycosylation called C-mannosylation modifies tryptophans in some signaling competent molecules and may be a further layer of complexity in the field. We will review each of these areas focusing on the glycan structures produced, the consequence of their presence, and the enzymes responsible.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.