Trial reportFree radical biology & medicine2009
Vitamin C treatment reduces elevated C-reactive protein.
Trial report in Free radical biology & medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01028976 (Obesity, Inflammation and Oxidative Stress), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Obesity, Inflammation and Oxidative Stress
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials.Scientific reports · 2020Pooled it
- Plasma proteomics analysis of vitamin C supplementation in people with type 2 diabetes.Nutrition & diabetes · 2026Trial
- Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial.Drug design, development and therapy · 2015Trial
- Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1.The American journal of clinical nutrition · 2011Trial
- Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial.European journal of nutrition · 2010Trial
- Adolescent obesity: Biochemical and dietary disparities in U.S. youth.Obesity pillars · 2026Article
- Synergistic Role of Aerobic Exercise and Vitamin C in Reducing Hypertension and Restoring Redox-Inflammatory Balance.Nutrients · 2026Article
- The association between fruit and vegetable intake and the odds of asthma among children and adolescents.Journal of health, population, and nutrition · 2025Article
- Blood Based Vascular Marker Responses to OcufolinBiomarker insights · 2025Article
- Forgotten Deficiency: A Case Series Highlighting Atypical Presentations of Scurvy in the 21st Century.Case reports in medicine · 2025Article
- The relationship between serum vitamin C levels and high-sensitivity C-reactive protein in children.Scientific reports · 2024Article
- The Role of Vitamins in the Pathogenesis of Asthma.International journal of molecular sciences · 2023Review
- Article
- The cross-sectional relationship between vitamin C and high-sensitivity C-reactive protein levels: insights from NHANES database.Frontiers in nutrition · 2023Article
- C-reactive protein: a target for therapy to reduce inflammation.Frontiers in immunology · 2023Review
- Decreasing Vitamin C Intake, Low Serum Vitamin C Level and Risk for US Adults with Diabetes.Nutrients · 2022Article
- The Variable Nature of Vitamin C-Does It Help When Dealing with Coronavirus?Antioxidants (Basel, Switzerland) · 2022Review
- Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003-2006 Surveys.Nutrients · 2022Article
- Article
- Dietary Factors Associated with Asthma Development: A Narrative Review and Summary of Current Guidelines and Recommendations.Journal of asthma and allergy · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Plasma C-reactive protein (CRP) is an inflammatory biomarker that predicts cardiovascular disease. Lowering elevated CRP with statins has reduced the incidence of cardiovascular disease. We investigated whether vitamin C or E could reduce CRP. Healthy nonsmokers (N=396) were randomized to three groups, 1000 mg/day vitamin C, 800 IU/day vitamin E, or placebo, for 2 months. Median baseline CRP was low, 0.85 mg/L. No treatment effect was seen when all participants were included. However, a significant interaction was found, indicating that treatment effect depends on baseline CRP concentration. Among participants with CRP indicative of elevated cardiovascular risk (> or =1.0 mg/L), vitamin C reduced the median CRP by 25.3% vs placebo (p=0.02) (median reduction in the vitamin C group, 0.25 mg/L, 16.7%). These effects are similar to those of statins. The vitamin E effect was not significant. In summary, treatment with vitamin C but not vitamin E significantly reduced CRP among individuals with CRP > or =1.0 mg/L. Among the obese, 75% had CRP > or =1.0 mg/L. Research is needed to determine whether reducing this inflammatory biomarker with vitamin C could reduce diseases associated with obesity. But research on clinical benefits of antioxidants should limit participants to persons with elevations in the target biomarkers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.