Evidence map›Paper›PMID 18952082›Full record

Trial reportGastroenterology2009

A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis.

Payal Bhardwaj, Pramod Kumar Garg, Subir Kumar Maulik, Anoop Saraya, Rakesh Kumar Tandon, Subrat Kumar Acharya

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01528540 (Evaluation of Efficacy of Combination of Pregabalin and Antioxidant in Reducing Pain in Chronic Pancreatitis), which is not on this map. Cited by 70 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 7 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01528540 nacompletednot on this mapstarted 2012, after this paper: background citation

Evaluation of Efficacy of Combination of Pregabalin and Antioxidant in Reducing Pain in Chronic Pancreatitis: a RCT

TypeinterventionalSponsorAsian Institute of Gastroenterology, IndiaRan2012 to 2014Enrolled87ConditionsChronic PancreatitisArmsPlacebo, Antioxidant plus Pregabalin
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 7 syntheses or guidelines pooled it, 254 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Antioxidants for pain in chronic pancreatitis.The Cochrane database of systematic reviews · 2014
    Pooled it
  4. Treatment options in painful chronic pancreatitis: a systematic review.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2014
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Reduction of inflammation in chronic pancreatitis using a soy bread intervention: A feasibility study.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2020
    Trial
  10. Trial
  11. Trial
  12. Review
  13. Article
  14. Innovations in pain management in patients with chronic pancreatitis.iGIE : innovation, investigation and insights · 2025
    Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Payal BhardwajDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Pramod Kumar Garg
Subir Kumar Maulik
Anoop Saraya
Rakesh Kumar Tandon
Subrat Kumar Acharya
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsOxidative stress has been implicated in the pathophysiology of chronic pancreatitis (CP). We evaluated the effects of antioxidant supplementation on pain relief, oxidative stress, and antioxidant status in patients with CP.

methodsIn a placebo-controlled double blind trial, consecutive patients with CP were randomized to groups that were given placebo or antioxidants for 6 months. The primary outcome measure was pain relief, and secondary outcome measures were analgesic requirements, hospitalization, and markers of oxidative stress (thiobarbituric acid-reactive substances [TBARS]) and antioxidant status (ferric-reducing ability of plasma [FRAP]).

resultsPatients (age 30.5+/-10.5 years, 86 male, 35 alcoholic, and 92 with idiopathic CP) were assigned to the placebo (n=56) or antioxidant groups (n=71). After 6 months, the reduction in the number of painful days per month was significantly higher in the antioxidant group compared with the placebo group (7.4+/-6.8 vs 3.2+/-4, respectively; P< .001; 95% CI, 2.07, 6.23). The reduction in the number of analgesic tablets per month was also higher in the antioxidant group (10.5+/-11.8 vs 4.4+/-5.8 respectively; P= .001; 95% CI, 2.65, 9.65). Furthermore, 32% and 13% of patients became pain free in the antioxidant and placebo groups, respectively (P= .009). The reduction in the level of TBARS and increase in FRAP were significantly higher in the antioxidant group compared with the placebo group (TBARS: placebo 1.2+/-2.7 vs antioxidant 3.5+/-3.4 nmol/mL; P= .001; 95% CI 0.96, 3.55; FRAP: placebo -5.6+/-154.9 vs antioxidant 97.8+/-134.9 microMFe(+2) liberated, P= .001, 95% CI 44.98, 161.7).

conclusionsAntioxidant supplementation was effective in relieving pain and reducing levels of oxidative stress in patients with CP.

Indexed as

AdultAnalgesicsAntioxidantsBiomarkersCalcium ChannelsDouble-Blind MethodFemaleHospitalizationHumansMaleNerve Tissue ProteinsOxidative StressPainPancreatitis, ChronicTransient Receptor Potential ChannelsTRPA1 Cation ChannelAnalgesicsAntioxidantsBiomarkersCalcium ChannelsNerve Tissue ProteinsTransient Receptor Potential ChannelsTRPA1 Cation ChannelTRPA1 protein, human

Identifiers

PMID18952082
OpenAlexW1986112329

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.