ArticleToxicology and applied pharmacology2009
Role of endoplasmic reticulum stress in acrolein-induced endothelial activation.
Article in Toxicology and applied pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- Differential transcriptomic alterations in nasal versus lung tissue of acrolein-exposed rats.Frontiers in toxicology · 2023Article
- Acrolein inhalation acutely affects the regulation of mitochondrial metabolism in rat lung.Toxicology · 2022Article
- Fine particulate matter (PMAmerican journal of physiology. Heart and circulatory physiology · 2021Article
- Acute and chronic vascular effects of inhaled crotonaldehyde in mice: Role of TRPA1.Toxicology and applied pharmacology · 2020Article
- Cardiac toxicity of acrolein exposure in embryonic zebrafish (Danio rerio).Environmental science and pollution research international · 2020Article
- Pathological Role of Unsaturated Aldehyde Acrolein in Diabetic Retinopathy.Frontiers in immunology · 2020Review
- Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells.Journal of lipid and atherosclerosis · 2020Article
- The Emerging Role of Electrophiles as a Key Regulator for Endoplasmic Reticulum (ER) Stress.International journal of molecular sciences · 2019Review
- Endoplasmic reticulum stress may be involved in insulin resistance and lipid metabolism disorders of the white adipose tissues induced by high-fat diet containing industrial trans-fatty acids.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Flavorings in Tobacco Products Induce Endothelial Cell Dysfunction.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance.Oxidative medicine and cellular longevity · 2018Review
- Biomarkers of Chronic Acrolein Inhalation Exposure in Mice: Implications for Tobacco Product-Induced Toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Oxidative stress and lipotoxicity.Journal of lipid research · 2016Review
- Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity.Scientific reports · 2016Article
- Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis.American journal of physiology. Heart and circulatory physiology · 2016Article
- Glutathione S-transferase P protects against cyclophosphamide-induced cardiotoxicity in mice.Toxicology and applied pharmacology · 2015Article
- Molecular mechanisms of acrolein toxicity: relevance to human disease.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- Enhancement of the acrolein-induced production of reactive oxygen species and lung injury by GADD34.Oxidative medicine and cellular longevity · 2015Article
- Acrolein decreases endothelial cell migration and insulin sensitivity through induction of let-7a.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Modulation of endothelial cell migration by ER stress and insulin resistance: a role during maternal obesity?Frontiers in pharmacology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Acrolein is a ubiquitous environmental pollutant and an endogenous product of lipid peroxidation. It is also generated during the metabolism of several drugs and amino acids. In this study, we examined the effects of acrolein on endothelial cells. Treatment of human umbilical vein endothelial cells (HUVECs) with 2 to 10 microM acrolein led to an increase in the phosphorylation of eIF-2alpha within 10 to 30 min of exposure. This was followed by alternate splicing of XBP-1 mRNA and an increase in the expression of the endoplasmic reticulum (ER) chaperone genes Grp78 and Herp. Within 2-4 h of treatment, acrolein also increased the abundance and the nuclear transport of the transcription factors ATF3, AFT4, and CHOP. Acrolein-induced increase in ATF3 was prevented by treating the cells with the chemical chaperone - phenylbutyric acid (PBA). Treatment with acrolein increased phosphorylation of ERK1/2, p38, and JNK. The increase in JNK phosphorylation was prevented by PBA. Acrolein treatment led to activation and nuclear translocation of the transcription factor NF-kappaB and an increase in TNF-alpha, IL-6 and IL-8, but not MCP-1, mRNA. Increased expression of cytokine genes and NF-kappaB activation were not observed in cells treated with PBA. These findings suggest that exposure to acrolein induces ER stress and triggers the unfolded protein response and that NF-kappaB activation and stimulation of cytokine production by acrolein could be attributed, in part, to ER stress. Chemical chaperones of protein-folding may be useful in treating toxicological and pathological states associated with excessive acrolein exposure or production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.