ReviewBurns : journal of the International Society for Burn Injuries2009
Gammadelta T-cells: potential regulators of the post-burn inflammatory response.
Review in Burns : journal of the International Society for Burn Injuries, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Topical glyceryl trinitrate treatment of chronic patellar tendinopathy: a randomised, double-blind, placebo-controlled clinical trial.British journal of sports medicine · 2013Trial
- Burn Selection: How Fire Injury Shaped Human Evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Unremitting pro-inflammatory T-cell phenotypes, and macrophage activity, following paediatric burn injury.Clinical & translational immunology · 2024Article
- Article
- Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at All Wound Healing Stages (Inflammation, Proliferation and Maturation).International journal of molecular sciences · 2021Review
- Altered Genes and Biological Functions in Response to Severe Burns.BioMed research international · 2021Article
- A Critical Update of the Assessment and Acute Management of Patients with Severe Burns.Advances in wound care · 2019Review
- The systemic immune response to pediatric thermal injury.International journal of burns and trauma · 2018Review
- The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury.International journal of molecular sciences · 2017Review
- Article
- Serum 25-Hydroxyvitamin D Levels in Pediatric Burn Patients.Trauma monthly · 2016Article
- Dermal γδ T-Cells Can Be Activated by Mitochondrial Damage-Associated Molecular Patterns.PloS one · 2016Article
- The association between the Th-17 immune response and pulmonary complications in a trauma ICU population.Cytokine · 2015Article
- The safety of allogeneic innate lymphocyte therapy for glioma patients with prior cranial irradiation.Cancer immunology, immunotherapy : CII · 2015Article
- Gamma delta T cells regulate wound myeloid cell activity after burn.Shock (Augusta, Ga.) · 2014Article
- Programmed downregulation of CCR6 is important for establishment of epidermal γδT cells by regulating their thymic egress and epidermal location.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Gamma delta (γδ) T-cells are critical in the up-regulation of inducible nitric oxide synthase at the burn wound site.Cytokine · 2012Article
- NK cells modulate the inflammatory response to corneal epithelial abrasion and thereby support wound healing.The American journal of pathology · 2012Article
- The Th-17 response and its potential role in post-injury pulmonary complications.International journal of burns and trauma · 2012Article
- Burn induces a Th-17 inflammatory response at the injury site.Burns : journal of the International Society for Burn Injuries · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Severe burn induces an immunopathological response that contributes to the development of a systemic inflammatory response (SIRS) and subsequent multiple organ failure. While, multiple immune cells type (T-cells, macrophages, neutrophils) are involved in this response, recent evidence suggests that a unique T-cell subset, gammadelta T-cells are central in the response to injury. While gammadelta T-cells represent only a small percentage of the total T-cell population, they display specific functional characteristics that uniquely position them in the immune/inflammatory axis to influence a number of important aspects of the body's response to burn. This review will focus on the potential regulator role of gammadelta T-cells in immunopathological response following burn and thereby their potential as therapeutic targets for affecting inflammation and healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.