ArticleExperimental hematology2009
Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells.
Article in Experimental hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Plasma Sclerostin in HIV-Infected Adults on Effective Antiretroviral Therapy.AIDS research and human retroviruses · 2015Trial
- Multiomics of Bohring-Opitz syndrome truncating ASXL1 mutations identify canonical and noncanonical Wnt signaling dysregulation.JCI insight · 2023Article
- Loss of Parathyroid Hormone Receptor Signaling in Osteoprogenitors Is Associated With Accumulation of Multiple Hematopoietic Lineages in the Bone Marrow.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Deficiency of TGR5 exacerbates immune-mediated cholestatic hepatic injury by stabilizing the β-catenin destruction complex.International immunology · 2020Article
- Human epithelial ovarian cancer cells expressing CD105, CD44 and CD106 surface markers exhibit increased invasive capacity and drug resistance.Oncology letters · 2019Article
- Review
- Interrelationship of canonical and non-canonical Wnt signalling pathways in chronic metabolic diseases.Diabetes & vascular disease research · 2018Review
- Dickkopf-3 Ablation Attenuates the Development of Atherosclerosis in ApoE-Deficient Mice.Journal of the American Heart Association · 2017Article
- Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Wnt signaling pathway in cancer.Critical reviews in oncology/hematology · 2016Review
- Modeling the Pro-inflammatory Tumor Microenvironment in Acute Lymphoblastic Leukemia Predicts a Breakdown of Hematopoietic-Mesenchymal Communication Networks.Frontiers in physiology · 2016Article
- PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Article
- Endothelial progenitor cell dysfunction in myelodysplastic syndromes: possible contribution of a defective vascular niche to myelodysplasia.Neoplasia (New York, N.Y.) · 2015Article
- Article
- Regulation of hematopoietic and leukemic stem cells by the immune system.Cell death and differentiation · 2015Review
- Distinct Patterns of Wnt3a and Wnt5a Signaling Pathway in the Lung from Rats with Endotoxic Shock.PloS one · 2015Article
- Early B lymphocyte development: Similarities and differences in human and mouse.World journal of stem cells · 2014Review
- c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface.Developmental cell · 2013Article
- VCAM1 expression correlated with tumorigenesis and poor prognosis in high grade serous ovarian cancer.American journal of translational research · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe Wnt family may contribute to hematopoietic stem cell (HSC) maintenance in bone marrow, but many questions remain concerning mechanisms. Vascular cell adhesion molecule-1 (VCAM-1) is expressed in cellular compartments of the bone marrow and might contribute to the HSC niche, but mechanisms concerning its constitutive expression are largely unknown. We now explore the influence of Wnt signaling on cellular adhesion molecule expression by bone marrow stromal and hematopoietic cells. MATERIALS AND
methodsRecombinant Wnt ligands, retroviral Wnt transductions and cocultures with Wnt-secreting cells were used to analyze the effect of Wnt on adhesion molecule expression by stromal and hematopoietic cells. In vivo experiments were also done to assess the ability of Wnt3a-induced, VCAM-1 deficient hematopoietic cells to engraft bone marrow.
resultsWe now report that the beta-catenin-dependent canonical Wnt signaling pathway negatively regulates VCAM-1 expression on two types of bone marrow cells. Wnt pathway inhibitors, Axin (intracellular) or Dickkopf-1 (extracellular) blocked the regulation of VCAM-1 by diffusible Wnt3a. Interestingly, lipopolysaccharide restored a substantial degree of VCAM-1 expression, suggesting functional cross-talk between Wnt and TLR4 signaling pathways. Decreasing VCAM-1 on HSC-enriched Lin(-) Sca-1(+) c-Kit(Hi) Thy1.1(Lo) cells by exposure to Wnt3a did not prevent their successful transplantation.
conclusionsOur results suggest that cells comprising and residing in the HSC niche can respond to Wnt ligands and extinguish VCAM-1. This response may be important for export of hematopoietic cells. Given the known contribution of VCAM-1 to inflammation, this may represent a new avenue for therapeutic intervention.
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