ArticleMolecular immunology2009
Characteristic motifs for families of allergenic proteins.
Article in Molecular immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 76 citations in OpenAlex.
- AllergenAI: a deep learning model predicting allergenicity based on protein sequence.BMC bioinformatics · 2025Article
- The updated Structural Database of Allergenic Proteins (SDAP 2.0) provides 3D models for allergens and incorporated bioinformatics tools.The journal of allergy and clinical immunology. Global · 2023Article
- Still SDAPing Along: 20 Years of the Structural Database of Allergenic Proteins.Frontiers in allergy · 2022Article
- Design of peptides with high affinity binding to a monoclonal antibody as a basis for immunotherapy.Peptides · 2021Article
- Nutritional, functional, and allergenic properties of silkworm pupae.Food science & nutrition · 2021Review
- The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds.The Journal of allergy and clinical immunology · 2021Review
- DGraph Clusters Flaviviruses and β-Coronaviruses According to Their Hosts, Disease Type, and Human Cell Receptors.Bioinformatics and biology insights · 2021Article
- D-graph clusters flaviviruses and β-coronaviruses according to their hosts, disease type and human cell receptors.bioRxiv : the preprint server for biology · 2020Article
- Distinguishing allergens from non-allergenic homologues using Physical-Chemical Property (PCP) motifs.Molecular immunology · 2018Article
- Article
- Functional classification of protein toxins as a basis for bioinformatic screening.Scientific reports · 2017Article
- Deep sequencing transcriptional fingerprinting of rice kernels for dissecting grain quality traits.BMC genomics · 2015Article
- Cross-reactivity between aeroallergens and food allergens.World journal of methodology · 2015Article
- Genome-wide analysis of potential cross-reactive endogenous allergens in rice (Toxicology reports · 2015Article
- IgE antibodies to mountain cedar pollen predominantly recognize multiple conformational epitopes on Jun a 1.The Journal of allergy and clinical immunology · 2014Article
- Assessment of 3D models for allergen research.Proteins · 2013Article
- Innate immunostimulatory properties of allergens and their relevance to food allergy.Seminars in immunopathology · 2012Review
- A molecular and proteomic investigation of proteins rapidly released from triticale pollen upon hydration.Plant molecular biology · 2012Article
- Group 10 allergens (tropomyosins) from house-dust mites may cause covariation of sensitization to allergens from other invertebrates.Allergy & rhinology (Providence, R.I.) · 2012Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The identification of potential allergenic proteins is usually done by scanning a database of allergenic proteins and locating known allergens with a high sequence similarity. However, there is no universally accepted cut-off value for sequence similarity to indicate potential IgE cross-reactivity. Further, overall sequence similarity may be less important than discrete areas of similarity in proteins with homologous structure. To identify such areas, we first classified all allergens and their subdomains in the Structural Database of Allergenic Proteins (SDAP, http://fermi.utmb.edu/SDAP/) to their closest protein families as defined in Pfam, and identified conserved physicochemical property motifs characteristic of each group of sequences. Allergens populate only a small subset of all known Pfam families, as all allergenic proteins in SDAP could be grouped to only 130 (of 9318 total) Pfams, and 31 families contain more than four allergens. Conserved physicochemical property motifs for the aligned sequences of the most populated Pfam families were identified with the PCPMer program suite and catalogued in the webserver MotifMate (http://born.utmb.edu/motifmate/summary.php). We also determined specific motifs for allergenic members of a family that could distinguish them from non-allergenic ones. These allergen specific motifs should be most useful in database searches for potential allergens. We found that sequence motifs unique to the allergens in three families (seed storage proteins, Bet v 1, and tropomyosin) overlap with known IgE epitopes, thus providing evidence that our motif based approach can be used to assess the potential allergenicity of novel proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.