ReviewSeminars in reproductive medicine2008
The expression and potential regulatory function of microRNAs in the pathogenesis of leiomyoma.
Review in Seminars in reproductive medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- Review
- MicroRNAs as potential indicators of the development and progression of uterine leiomyoma.PloS one · 2022Article
- Tranilast induces MiR-200c expression through blockade of RelA/p65 activity in leiomyoma smooth muscle cells.Fertility and sterility · 2020Article
- The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids-From Bench to Bedside.International journal of molecular sciences · 2020Review
- Phthalate Exposures and MicroRNA Expression in Uterine Fibroids: The FORGE Study.Epigenetics insights · 2020Article
- Cross-talk between miR-29c and transforming growth factor-β3 is mediated by an epigenetic mechanism in leiomyoma.Fertility and sterility · 2019Article
- MiR-150-5p May Contribute to Pathogenesis of Human Leiomyoma via Regulation of the Akt/p27International journal of molecular sciences · 2019Article
- Regulation of Cell Cycle Regulatory Proteins by MicroRNAs in Uterine Leiomyoma.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Next-generation sequencing reveals differentially expressed small noncoding RNAs in uterine leiomyoma.Fertility and sterility · 2018Article
- Screening of potential biomarkers in uterine leiomyomas disease via gene expression profiling analysis.Molecular medicine reports · 2018Article
- Recent Advances in Uterine Fibroid Etiology.Seminars in reproductive medicine · 2017Review
- The Rising Phoenix-Progesterone as the Main Target of the Medical Therapy for Leiomyoma.BioMed research international · 2017Review
- Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval.Endocrine-related cancer · 2015Article
- BET1L and TNRC6B associate with uterine fibroid risk among European Americans.Human genetics · 2013Article
- Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5.Endocrine-related cancer · 2012Article
- The role of progesterone signaling in the pathogenesis of uterine leiomyoma.Molecular and cellular endocrinology · 2012Review
- miR-93/106b and their host gene, MCM7, are differentially expressed in leiomyomas and functionally target F3 and IL-8.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells.Journal of signal transduction · 2012Article
- Minireview: The roles of small RNA pathways in reproductive medicine.Molecular endocrinology (Baltimore, Md.) · 2011Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Leiomyomas are benign uterine tumors considered to arise from transformation of myometrial cells. What initiates the conversion of myometrial cells into leiomyoma is unknown, however cytogenetic analysis often shows occurrence of nonrandom chromosomal abnormalities that may account for their establishment. It is clear that ovarian steroids are essential for leiomyoma growth, and local expression of many autocrine/paracrine mediators serving as key regulators of cell-cycle progression, cellular hypertrophy, extracellular matrix accumulation, and apoptosis appear to play central roles in this capacity. However, the stability of the expression of these genes represents the hallmarks of leiomyoma establishment, growth, and regression. With the emergence of microRNA (miRNA) as a key regulator of gene expression stability, in this review we present evidence for the expression and potential regulatory functions on miRNAs in leiomyoma with particular emphasis on the expression of their selective target genes whose products influence various cellular activities critical to pathogenesis of leiomyomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.