ArticleCurrent biology : CB2008
Actin dynamics is essential for myosin-based transport of membrane organelles.
Article in Current biology : CB, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 70 citations in OpenAlex.
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- On-Demand Photoactivation of DNA-Based Motor Motion.ACS nano · 2025Article
- Human congenital cataract mutation inInternational journal of ophthalmology · 2025Article
- Wnt5A signaling supports antigen processing and CD8 T cell activation.Frontiers in immunology · 2022Article
- Roles and regulation of myosin V interaction with cargo.Advances in biological regulation · 2021Review
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- F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis.Science advances · 2020Article
- Cell-Inspired All-Aqueous Microfluidics: From Intracellular Liquid-Liquid Phase Separation toward Advanced Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Quantifying Retinal Pigment Epithelium Dysmorphia and Loss of Histologic Autofluorescence in Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2019Article
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- Mechanical principles of nuclear shaping and positioning.The Journal of cell biology · 2018Review
- Activity-Dependence of Synaptic Vesicle Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Tau physiology and pathomechanisms in frontotemporal lobar degeneration.Journal of neurochemistry · 2016Review
- Abnormal intermediate filament organization alters mitochondrial motility in giant axonal neuropathy fibroblasts.Molecular biology of the cell · 2016Article
- Interaction between MyRIP and the actin cytoskeleton regulates Weibel-Palade body trafficking and exocytosis.Journal of cell science · 2016Article
- The Role of the Cytoskeleton and Myosin-Vc in the Targeting of KCa3.1 to the Basolateral Membrane of Polarized Epithelial Cells.Frontiers in physiology · 2016Article
- Bidirectional actin transport is influenced by microtubule and actin stability.Cellular and molecular life sciences : CMLS · 2015Article
- Microtubules Negatively Regulate Insulin Secretion in Pancreatic β Cells.Developmental cell · 2015Article
- Actin age orchestrates myosin-5 and myosin-6 run lengths.Current biology : CB · 2015Article
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8 authors at 4 institutions in 2 countries.
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Abstract
Actin filaments that serve as "rails" for the myosin-based transport of membrane organelles [1-4] continuously turn over by concurrent growth and shortening at the opposite ends [5]. Although it is known that dynamics of actin filaments is essential for many of the actin cytoskeleton functions, the role of such dynamics in myosin-mediated organelle transport was never studied before. Here, we addressed the role of turnover of actin filaments in the myosin-based transport of membrane organelles by treating cells with the drugs that suppress actin-filament dynamics and found that such a suppression significantly inhibited organelle transport along the actin filaments without inhibiting their intracellular distribution or the activity of the myosin motors. We conclude that dynamics of actin filaments is essential for myosin-based transport of membrane organelles and suggest a previously unknown role of actin-filament dynamics in providing the "rails" for continuous organelle movement resulting in the increased distances traveled by membrane organelles along the actin filaments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.