ArticleThe Journal of pediatrics2009
Associations between multiple environmental exposures and Glutathione S-Transferase P1 on persistent wheezing in a birth cohort.
Article in The Journal of pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review.Current allergy and asthma reports · 2018Pooled it
- Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.PloS one · 2012Pooled it
- Glutathione-S-transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data.International journal of epidemiology · 2010Pooled it
- Gene-air pollution interaction and cardiovascular disease: a review.Progress in cardiovascular diseasesPooled it
- Passive Tobacco Smoke Exposure, Oxidative Stress and Pediatric Allergic and Obstructive Respiratory Diseases: A Systematic Review and a "Second Oxidative Hit" Hypothesis.Antioxidants (Basel, Switzerland) · 2026Review
- Health effects associated with exposure to secondhand smoke: a Burden of Proof study.Nature medicine · 2024Article
- Interactions between glutathione S-transferase genes and household air pollution on asthma and lung function.Frontiers in molecular biosciences · 2022Review
- Glutathione S-Transferase Gene Associations and Gene-Environment Interactions for Asthma.Current allergy and asthma reports · 2021Review
- Household mold, pesticide use, and childhood asthma: A nationwide study in the U.S.International journal of hygiene and environmental health · 2021Article
- Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes.Disease markers · 2021Article
- The morbidity and mortality of COVID-19 are correlated with the Ile105Val glutathioneThe Egyptian journal of medical human genetics · 2020Article
- Indoor mould exposure, asthma and rhinitis: findings from systematic reviews and recent longitudinal studies.European respiratory review : an official journal of the European Respiratory Society · 2018Review
- Interactions Between Bisphenol A Exposure and GSTP1 Polymorphisms in Childhood Asthma.Allergy, asthma & immunology research · 2018Article
- Association between Traffic Related Air Pollution and the Development of Asthma Phenotypes in Children: A Systematic Review.International journal of chronic diseases · 2018Review
- Do Variants in GSTs Modify the Association between Traffic Air Pollution and Asthma in Adolescence?International journal of molecular sciences · 2016Article
- The Interaction Between Prenatal Exposure to Home Renovation and Reactive Oxygen Species Genes in Cord Blood IgE Response is Modified by Maternal Atopy.Allergy, asthma & immunology research · 2016Article
- Modification of additive effect between vitamins and ETS on childhood asthma risk according to GSTP1 polymorphism: a cross -sectional study.BMC pulmonary medicine · 2015Article
- Timing and Duration of Traffic-related Air Pollution Exposure and the Risk for Childhood Wheeze and Asthma.American journal of respiratory and critical care medicine · 2015Article
- Environmental effects on immune responses in patients with atopy and asthma.The Journal of allergy and clinical immunology · 2014Review
- GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study.Environmental health perspectives · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine the impact of environmental exposures (diesel exhaust particle [DEP], environmental tobacco smoke [ETS], and mold) that may contribute to oxidative stress on persistent wheezing in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) birth cohort and to determine how the impact of these exposures is modified by the GST-P1 Ile105Val polymorphism. STUDY
designA land-use regression model was used to derive an estimate of each child's DEP exposure. ETS exposure was determined by questionnaire data. Each child's home was evaluated for visible mold by a trained professional. Children in the CCAAPS cohort were genotyped for the GST-P1 polymorphism (n = 570). Persistent wheezing was defined as wheezing at both 12 and 24 months.
resultsHigh DEP exposure conferred increased risk for wheezing phenotypes but only among the Val(105) allele carriers. Infants with multiple exposures were significantly more likely to persistently wheeze despite their genotype.
conclusionThere is evidence for an environmental effect of DEP among carriers of the GST-P1 Val(105) allele in the development of persistent wheezing in children. The protective effect of the GST-P1 Ile(105) genotype may be overwhelmed by multiple environmental exposures that converge on oxidative stress pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.