ArticleNeuroscience2008
Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brain.
Article in Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Dietary tryptophan intervention counteracts stress-induced transcriptional changes in a teleost fish HPI axis during inflammation.Scientific reports · 2024Article
- Inflammation, lipids, and pain in vulvar disease.Pharmacology & therapeutics · 2023Review
- Prostaglandin EDNA and cell biology · 2023Article
- Fever During Localized Inflammation in Mice Is Elicited by a Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and Interleukin-6 Signaling and Central EPThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Neural Mechanisms of Inflammation-Induced Fever.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Sex differences in innate immunity and its impact on opioid pharmacology.Journal of neuroscience research · 2017Review
- Thermoregulation as a disease tolerance defense strategy.Pathogens and disease · 2016Review
- Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo.Scientific reports · 2015Article
- Chronic inflammation aggravates metabolic disorders of hepatic fatty acids in high-fat diet-induced obese mice.Scientific reports · 2015Article
- The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis.Genes & diseases · 2014Review
- In-depth conversation: spectrum and kinetics of neuroimmune afferent pathways.Brain, behavior, and immunity · 2014Review
- Neural and behavioral responses to low-grade inflammation.Behavioural brain research · 2012Article
- Inflammatory stress exacerbates ectopic lipid deposition in C57BL/6J mice.Lipids in health and disease · 2011Article
- Effects of intravenous Escherichia coli dose on the pathophysiological response of colostrum-fed Jersey calves.Veterinary immunology and immunopathology · 2011Article
- Location-specific activation of the paraventricular nucleus of the hypothalamus by localized inflammation.Brain, behavior, and immunity · 2010Article
- Involvement of mitogen-activated protein kinases and nuclear factor kappa B pathways in signaling COX-2 expression in chronic rhinosinusitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2009Article
- Three Promoters Regulate Tissue- and Cell Type-specific Expression of Murine Interleukin-1 Receptor Type I.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The CNS can be activated by both local and systemic inflammation, resulting in the manifestation of sickness symptoms. The pathways by which the CNS is activated under these two conditions, however, may differ. In this study, we injected casein into the peritoneal cavity (i.p.) or into an s.c. air pouch of mice to induce restricted local inflammation. Both routes of casein injection caused fever and reduced locomotor activity. These responses were not accompanied by the statistically significant induction of the inflammatory cytokine interleukin-1 (IL-1) in the blood and brain. Further, these responses were produced without the induction of brain cyclooxygenase-2 (COX-2), which has been implicated as an obligatory step in systemic inflammation-induced activation of the CNS. Induction of IL-1, interleukin-6 (IL-6), and COX-2, however, was found consistently at the sites of casein injection. The local inflammation-induced febrile and locomotor activity responses were blunted in animals deficient in functional Toll-like receptor 4 (TLR4), type I interleukin-1 receptor (IL-1R1), IL-6, or COX-2. Therefore, the observed febrile and locomotor activity effects appear to require local, but not central, IL-1, IL-6, and COX-2. These findings suggest that local inflammation can activate the CNS via pathways distinguishable from those mediating systemic inflammation-induced CNS activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.