ArticleGastroenterology2009
Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association.
Article in Gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Prevalence of Celiac Disease in Patients With Iron Deficiency Anemia-A Systematic Review With Meta-analysis.Gastroenterology · 2018Pooled it
- Malignancies in Celiac Disease-A Hidden Threat with Diagnostic Pitfalls.Biomedicines · 2025Review
- Malignancies in Patients with Celiac Disease: Diagnostic Challenges and Molecular Advances.Genes · 2023Review
- Review
- Enteropathy-Associated T cell Lymphoma.Current hematologic malignancy reports · 2021Review
- Review
- Association Between Celiac Disease and Cancer.International journal of molecular sciences · 2020Review
- Forskolin exerts anticancer roles in non-Hodgkin's lymphomas via regulating Axin/β-catenin signaling pathway.Cancer management and research · 2019Article
- Descriptive Study of the Different Tools Used to Evaluate the Adherence to a Gluten-Free Diet in Celiac Disease Patients.Nutrients · 2018Review
- Pathogenesis of Enteropathy-Associated T Cell Lymphoma.Current hematologic malignancy reports · 2018Review
- Article
- Therapeutic approaches for celiac disease.Best practice & research. Clinical gastroenterology · 2015Review
- Risk of lymphoproliferative malignancy in celiac patients with a family history of lymphoproliferative malignancy.Journal of gastroenterology · 2013Article
- Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study.Annals of internal medicine · 2013Article
- Does celiac disease influence survival in lymphoproliferative malignancy?European journal of epidemiology · 2013Article
- Geographic trends and risk of gastrointestinal cancer among patients with celiac disease in Europe and Asian-Pacific region.Gastroenterology and hepatology from bed to bench · 2013Review
- Celiac disease: prevalence, diagnosis, pathogenesis and treatment.World journal of gastroenterology · 2012Review
- Multiple associations between a broad spectrum of autoimmune diseases, chronic inflammatory diseases and cancer.Anticancer research · 2012Review
- Recent advances in celiac disease.World journal of gastroenterology · 2011Article
- The characterization of the repertoire of wheat antigens and peptides involved in the humoral immune responses in patients with gluten sensitivity and Crohn's disease.ISRN allergy · 2011Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimsCeliac disease (CD), a common digestive disease, is well known to be associated with excess non-Hodgkin lymphoma (NHL) risk. However, there are only limited data on risk in the current era of serologic testing and human leukocytes antigen typing to screen for CD. There is also no information on the role of family history of CD in relation to lymphoma risk.
methodsWe identified 37,869 NHL, 8323 Hodgkin lymphoma (HL), and 13,842 chronic lymphocytic leukemia patients diagnosed in Sweden between 1965 and 2004, as well as 236,408 matched controls and 613,961 first-degree relatives. Using logistic regression, we calculated odds ratios and 95% confidence intervals as measures of risks adjusted for matching factors.
resultsOverall we found persons with a hospital discharge diagnosis of CD to have a 5.35-fold (95% CI, 3.56-8.06) increased NHL risk. Risk of HL was borderline increased (OR=2.54, 95% CI, 0.99-6.56); however, there was no excess chronic lymphocytic leukemia risk. Persons diagnosed with CD in 1975-1984, 1985-1994, and 1995-2004 had a 13.2-fold (95% CI, 3.63-48.0), 7.90-fold (95% CI, 3.38-18.5), and 3.84-fold (95% CI, 2.28-6.45) increased risk of NHL, respectively (P(trend)< .0001). Individuals with a sibling affected with CD had a 2.03-fold (95% CI, 1.29-3.19) increased NHL risk.
conclusionsPersons with CD have an increased NHL risk; however, the excess risk has tapered off substantially in the last 4 decades. The observed excess NHL risk among individuals with a sibling affected with CD suggests shared susceptibility. Future studies are needed to explore the roles of gluten intake, secondary intestinal inflammation, and susceptibility genes in relation to subsequent risk of developing lymphoma.
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