ArticleThe international journal of neuropsychopharmacology2009
Antidepressant drugs with differing pharmacological actions decrease activity of locus coeruleus neurons.
Article in The international journal of neuropsychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 98 citations in OpenAlex.
- Subanesthetic Ketamine Suppresses Locus Coeruleus-Mediated Alertness Effects: A 7T fMRI Study.The international journal of neuropsychopharmacology · 2024Trial
- A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms.Molecular psychiatry · 2026Review
- Antidepressant medications have differential effects on REM sleep without atonia quantified by chin and upper extremity EMG.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Case Report: Delirium and complications resulting from the abuse of compound liquorice tablets.Frontiers in psychiatry · 2026Article
- Locus coeruleus noradrenaline depletion and its differential impact on COProgress in neuro-psychopharmacology & biological psychiatry · 2024Article
- Neurobiological Underpinnings of Hyperarousal in Depression: A Comprehensive Review.Brain sciences · 2024Review
- Chronic treatment with escitalopram and venlafaxine affects the neuropeptide S pathway differently in adult Wistar rats exposed to maternal separation.AIMS neuroscience · 2022Article
- Noradrenergic circuits in the forebrain control affective responses to novelty.Psychopharmacology · 2020Article
- Modulation of Monoaminergic Systems by Antidepressants in the Frontal Cortex of Rats After Chronic Mild Stress Exposure.Molecular neurobiology · 2019Article
- Sex differences in fear extinction.Neuroscience and biobehavioral reviews · 2019Review
- Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Stress induced neural reorganization: A conceptual framework linking depression and Alzheimer's disease.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats.The international journal of neuropsychopharmacology · 2017Article
- Brain arousal regulation as response predictor for antidepressant therapy in major depression.Scientific reports · 2017Article
- Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.Brain research · 2016Review
- Article
- Neuronal correlates of depression.Cellular and molecular life sciences : CMLS · 2015Review
- Prenatal exposure to serotonin reuptake inhibitor antidepressants and childhood behavior.Pediatric research · 2015Article
- Inflammatory Factors Mediate Vulnerability to a Social Stress-Induced Depressive-like Phenotype in Passive Coping Rats.Biological psychiatry · 2015Article
- GABAB receptor-mediated tonic inhibition regulates the spontaneous firing of locus coeruleus neurons in developing rats and in citalopram-treated rats.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies suggest that all effective antidepressant (AD) drugs decrease activity of locus coeruleus (LC) neurons. However, little data exist regarding blood levels of drug in these studies, and what data do exist suggest blood levels might have been very high. To assess whether decreased LC activity is produced by drugs that selectively block reuptake for either norepinephrine or serotonin at therapeutically relevant blood levels, effects of chronic administration of desipramine, paroxetine, and escitalopram on LC activity were measured across a range of doses and blood levels of drug. Further, effects of a range of doses of mirtazapine were examined; in that mirtazapine blocks alpha2 adrenergic receptors, it might be anticipated to increase rather than decrease LC activity. Finally, to begin to assess whether the response of LC to ADs was specific to these drugs, effects of four non-AD drugs (single dose) were measured. Drugs were administered via osmotic minipump for 14 d. Electrophysiological recording of LC activity (assessment of both spontaneous firing rate and sensory-evoked 'burst' firing) then took place under isoflurane anaesthesia on the last day of drug treatment. The blood level of drugs present at the end of the recording session was also measured. All AD drugs tested decreased LC spontaneous and sensory-evoked 'burst' firing, and this was observed across a wide range of blood levels for the drugs. Non-AD drugs did not decrease LC activity. The findings of this investigation continue to support the possibility that all effective AD drugs decrease LC activity.
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