Evidence map›Paper›PMID 18950517›Full record

ReviewVirology journal2008

Respiratory syncytial virus glycoproteins uptake occurs through clathrin-mediated endocytosis in a human epithelial cell line.

Abel Gutiérrez-Ortega, Carla Sánchez-Hernández, Beatriz Gómez-García

Open access · goldAbstract readReview
In one paragraph

Review in Virology journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
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  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Annexin A2 in Virus Infection.Frontiers in microbiology · 2018
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Motoneurons secrete angiogenin to induce RNA cleavage in astroglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Abel Gutiérrez-OrtegaDepartamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Circuito Interior, Ciudad Universitaria, DF México, México. agutierrster@gmail.com
Carla Sánchez-Hernández
Beatriz Gómez-García
Universidad Autónoma de la Ciudad de México · MXUniversidad de Guadalajara · MXUniversidad Nacional Autónoma de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-surface viral proteins most frequently enter the cell through clathrin or caveolae endocytosis. Respiratory syncytial virus antigen internalization by immune cells is via caveolin, however, uptake of paramyxovirus cell membrane proteins by non-immune cells is done through clathrin-coated pits. In this work, the uptake of respiratory syncytial virus cell surface glycoproteins by non-immune human epithelial cells was investigated through indirect immunofluorescence with polyclonal anti-RSV antibody and confocal lasser-scanner microscopy. Clathrin and caveolae internalization pathways were monitored through specific inhibitors monodansylcadaverine (MDC) and methyl-beta-cyclodextrin (MBCD), respectively. Internalization of RSV antigens was inhibited by MDC but not by MBCD, implying that clathrin-mediated endocytosis is the major uptake route of RSV antigens by an epithelial human cell line.

Indexed as

Endocytosisbeta-CyclodextrinsCadaverineCell LineClathrin-Coated VesiclesEnzyme InhibitorsEpithelial CellsFluorescent Antibody Technique, IndirectGlycoproteinsHumansMicroscopy, ConfocalRespiratory Syncytial VirusesViral Proteinsbeta-CyclodextrinsCadaverineEnzyme InhibitorsGlycoproteinsmethyl-beta-cyclodextrinmonodansylcadaverineViral Proteins

Identifiers

PMID18950517
PMCPMC2584630
OpenAlexW2130087463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.