Evidence map›Paper›PMID 18949582›Full record

ArticleNeuroinformatics2008

NeuroMorpho.Org implementation of digital neuroscience: dense coverage and integration with the NIF.

Maryam Halavi, Sridevi Polavaram, Duncan E Donohue, Gail Hamilton, Jeffrey Hoyt, Kenneth P Smith, Giorgio A Ascoli

Abstract read
In one paragraph

Article in Neuroinformatics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Efficient metadata mining of web-accessible neural morphologies.Progress in biophysics and molecular biology · 2022
    Article
  9. Data Management Schema Design for Effective Nanoparticle Formulation for Neurotherapeutics.AIChE journal. American Institute of Chemical Engineers · 2021
    Article
  10. Article
  11. Highlights from the Era of Open Source Web-Based Tools.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Mining Big Neuron Morphological Data.Computational intelligence and neuroscience · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maryam HalaviCenter for Neural Informatics, Structure, & Plasticity, and Molecular Neuroscience Department, Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA.
Sridevi Polavaram
Duncan E Donohue
Gail Hamilton
Jeffrey Hoyt
Kenneth P Smith
Giorgio A Ascoli

Funding

Generation and Description of Neuronal Morphology and ConnectivityR01NS039600 · NINDS · GEORGE MASON UNIVERSITY · PI ASCOLI, GIORGIO A · 1999 to 2024
$6.9M
A System to Share and Explore Human Brain Mapping DataR01MH064417 · NIMH · MITRE CORPORATION · PI SMITH, KEN · 2001 to 2005
$3.0M
NIDA NIH HHS HHSN271200577531CNIMH NIH HHS R01 MH064417NIMH NIH HHS R01 MH64417NINDS NIH HHS R01 NS039600NINDS NIH HHS R01 NS39600
6 · The paper itself

Abstract

Neuronal morphology affects network connectivity, plasticity, and information processing. Uncovering the design principles and functional consequences of dendritic and axonal shape necessitates quantitative analysis and computational modeling of detailed experimental data. Digital reconstructions provide the required neuromorphological descriptions in a parsimonious, comprehensive, and reliable numerical format. NeuroMorpho.Org is the largest web-accessible repository service for digitally reconstructed neurons and one of the integrated resources in the Neuroscience Information Framework (NIF). Here we describe the NeuroMorpho.Org approach as an exemplary experience in designing, creating, populating, and curating a neuroscience digital resource. The simple three-tier architecture of NeuroMorpho.Org (web client, web server, and relational database) encompasses all necessary elements to support a large-scale, integrate-able repository. The data content, while heterogeneous in scientific scope and experimental origin, is unified in format and presentation by an in house standardization protocol. The server application (MRALD) is secure, customizable, and developer-friendly. Centralized processing and expert annotation yields a comprehensive set of metadata that enriches and complements the raw data. The thoroughly tested interface design allows for optimal and effective data search and retrieval. Availability of data in both original and standardized formats ensures compatibility with existing resources and fosters further tool development. Other key functions enable extensive exploration and discovery, including 3D and interactive visualization of branching, frequently measured morphometrics, and reciprocal links to the original PubMed publications. The integration of NeuroMorpho.Org with version-1 of the NIF (NIFv1) provides the opportunity to access morphological data in the context of other relevant resources and diverse subdomains of neuroscience, opening exciting new possibilities in data mining and knowledge discovery. The outcome of such coordination is the rapid and powerful advancement of neuroscience research at both the conceptual and technological level.

Indexed as

AnimalsComputational BiologyDatabases as TopicHumansInformation Storage and RetrievalInternetMeta-Analysis as TopicNeuroanatomyNeuronsNeurosciencesSoftware

Identifiers

PMID18949582
PMCPMC2655120

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.