ArticleNeurochemical research2009
Kaempferol induces cell death through ERK and Akt-dependent down-regulation of XIAP and survivin in human glioma cells.
Article in Neurochemical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 99 citations in OpenAlex.
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- The Small Molecules of Plant Origin with Anti-Glioma Activity.International journal of molecular sciences · 2025Review
- The Anticancer Potential of Kaempferol: A Systematic Review Based on In Vitro Studies.Cancers · 2024Review
- Kaempferol and Biomodified Kaempferol fromInternational journal of molecular sciences · 2023Article
- Evaluation of Biological Activities of Twenty Flavones and In Silico Docking Study.Molecules (Basel, Switzerland) · 2023Article
- Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases.Beni-Suef University journal of basic and applied sciences · 2023Review
- Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways.Molecules (Basel, Switzerland) · 2022Review
- A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound.Cancer cell international · 2022Review
- Anticancer activity of flavonoids accompanied by redox state modulation and the potential for a chemotherapeutic strategy.Food science and biotechnology · 2021Review
- Cancer Chemoprevention: A Strategic Approach Using Phytochemicals.Frontiers in pharmacology · 2021Review
- Current Progress of Phytomedicine in Glioblastoma Therapy.Current medical science · 2020Review
- Tick-Borne Flaviviruses Depress AKT Activity during Acute Infection by Modulating AKT1/2.Viruses · 2020Article
- Antiproliferative and apoptogenic effects of Cassia fistula L. n-hexane fraction against human cervical cancer (HeLa) cells.Environmental science and pollution research international · 2020Article
- Antioxidant, Antiproliferative and Apoptosis-Inducing Efficacy of Fractions fromAntioxidants (Basel, Switzerland) · 2020Article
- Anti-glioblastoma Activity of Kaempferol via Programmed Cell Death Induction: Involvement of Autophagy and Pyroptosis.Frontiers in bioengineering and biotechnology · 2020Article
- Kaempferol: A Key Emphasis to Its Anticancer Potential.Molecules (Basel, Switzerland) · 2019Review
- Flavonoids in Cancer and Apoptosis.Cancers · 2018Review
- Dihydromyricetin enhances glucose uptake by inhibition of MEK/ERK pathway and consequent down-regulation of phosphorylation of PPARγ in 3T3-L1 cells.Journal of cellular and molecular medicine · 2018Article
- Treatment mechanism of matrine in combination with irinotecan for colon cancer.Oncology letters · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was undertaken to determine the molecular mechanism by which kaempferol induces cell death in human glioma cells. Kaempferol resulted in loss of cell viability and inhibition of proliferation in a dose- and time-dependent manner, which were largely attributed to cell death. Kaempferol caused an increase in reactive oxygen species (ROS) generation and the kaempferol-induced cell death was prevented by antioxidants, suggesting that ROS generation is involved in kaempferol-induced cell death. Kaempferol caused depolarization of mitochondrial membrane potential. Western blot analysis showed that kaempferol treatment caused a rapid reduction in phosphorylation of extracellular signal-regulated kinase (ERK) and Akt. The ERK inhibitor U0126 and the Akt inhibitor LY984002 increased the kaempferol-induced cell death and overexpression of MEK, the upstream kinase of ERK, and Akt prevented the cell death. The expression of anti-apoptotic proteins XIAP and survivin was down-regulated by kaempferol and its effect was prevented by overexpression of MEK and Akt. Kaempferol induced activation of caspase-3 and kaempferol-induced cell death was prevented by caspase inhibitors. Taken together, these findings suggest that kaempferol results in human glioma cell death through caspase-dependent mechanisms involving down-regulation of XIAP and survivin regulating by ERK and Akt.
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Registered trials
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