ArticleJournal of genetic counseling2009
Perceptions of familial risk in those seeking a genetic risk assessment for Alzheimer's disease.
Article in Journal of genetic counseling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Knowledge and perception of dementia risk and protective factors: a systematic review and meta-analysis.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Clinical implications of APOE genotyping for late-onset Alzheimer's disease (LOAD) risk estimation: a review of the literature.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Predictors of genetic testing decisions: a systematic review and critique of the literature.Journal of genetic counseling · 2014Pooled it
- Attitudes of Family Members and Caregivers Regarding Alzheimer's Disease Pre-Symptomatic Screening.Journal of Alzheimer's disease reports · 2024Article
- Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer's disease.Brain communications · 2023Article
- Correlates of Dementia-related Anxiety: Self-Perceived Dementia Risk and Ageism.Educational gerontology · 2020Article
- The Influence of Psychosocial and Cognitive Factors on Perceived Threat of Alzheimer's Disease.American journal of Alzheimer's disease and other dementias · 2017Article
- Consumer Perspectives on Access to Direct-to-Consumer Genetic Testing: Role of Demographic Factors and the Testing Experience.The Milbank quarterly · 2017Article
- Exploring the post-genomic world: differing explanatory and manipulatory functions of post-genomic sciences.New genetics and society · 2016Article
- Perceptions of tissue storage in a dementia population among spouses and offspring.Journal of genetic counseling · 2015Article
- Public perceptions of presymptomatic testing for Alzheimer disease.Mayo Clinic proceedings · 2014Article
- Perceptions of genetic research in three rural Appalachian Ohio communities.Journal of community genetics · 2013Article
- Effect of pre-test genetic counseling for deaf adults on knowledge of genetic testing.Journal of genetic counseling · 2012Article
- The role of distress in uptake and response to predisposition genetic testing: the BMPR2 experience.Genetic testing and molecular biomarkers · 2012Article
- Appraisal of cognition in preclinical Alzheimer's disease: a conceptual review.Neurodegenerative disease management · 2012Article
- Family history, perceived risk, and perceived threat of Alzheimer's disease among Latino residents of northern Manhattan.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Perceived risk is a complex concept that influences the genetic counseling process and can affect client coping and behavior. Although the association between family history and risk perception is well recognized in the literature, no studies have explored this relationship specifically in those seeking genetic susceptibility testing for a common chronic condition. REVEAL is a randomized trial assessing the impact of APOE disclosure and genetic risk assessment for Alzheimer's disease (AD). Using baseline REVEAL data, we hypothesized that there would be a significant association between the degree of AD family history and risk perception of AD, and that this relationship would be stronger in those who believed that genetics is a very important AD risk factor. In our sample of 293 participants, we found that a higher self-perceived risk of AD was associated with strength of family history of AD (p < 0.001), belief in genetics as an important AD risk factor (p < 0.001), being female (p < 0.001) and being Caucasian (p = 0.02). These results are the first to demonstrate the association between family history and risk perception in persons volunteering for genetic susceptibility testing for a common complex disease.
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Registered trials
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