Evidence map›Paper›PMID 18949449›Full record

Trial reportInternational journal of hematology2008

BCL10 nuclear expression and t(11;18)(q21;q21) indicate nonresponsiveness to Helicobacter pylori eradication of Chinese primary gastric MALT lymphoma.

Gehong Dong, Cuiling Liu, Hongtao Ye, Liping Gong, Jie Zheng, Min Li, Xin Huang, Xuebiao Huang, Yuanjie Huang, Yunfei Shi and 2 more

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in International journal of hematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gehong DongDepartment of Pathology, Peking University Health Science Center, 100191, Beijing, People's Republic of China.
Cuiling LiuDepartment of Pathology, Peking University Health Science Center, 100191, Beijing, People's Republic of China.
Hongtao YeDivision of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK.
Liping GongDepartment of Pathology, Capital Medical University, 100069, Beijing, People's Republic of China.
Jie ZhengDepartment of Pathology, Peking University Health Science Center, 100191, Beijing, People's Republic of China.
Min LiDepartment of Pathology, Peking University Health Science Center, 100191, Beijing, People's Republic of China.
Xin HuangDepartment of Pathology, Peking University Health Science Center, 100191, Beijing, People's Republic of China.
Xuebiao HuangDepartment of Digestive Disease, Peking University Third Hospital, 100191, Beijing, People's Republic of China.
Yuanjie HuangDepartment of Pathology, Peking University Health Science Center, 100191, Beijing, People's Republic of China.
Yunfei ShiDepartment of Pathology, Peking University Health Science Center, 100191, Beijing, People's Republic of China.
Wenjuan YinDepartment of Pathology, Peking University Health Science Center, 100191, Beijing, People's Republic of China.
Zifen GaoDepartment of Pathology, Peking University Health Science Center, 100191, Beijing, People's Republic of China. wjshgao@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The eradication of Helicobacter pylori (H. pylori) with antibiotics induces complete remission in 75% of patients with gastric MALT lymphoma. We investigated the efficacy of H. pylori eradication and assessed the predictive value of BCL10 nuclear expression and t(11;18)(q21;q21) regarding resistance to H. pylori eradication in primary gastric mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) patients from mainland China. Twenty-two gastric MALT cases (Stage I(E)) underwent H. pylori eradication with antibiotics, and sequential endoscopic-bioptic follow-ups were performed and assessed with regular morphologic and immunohistochemical examinations. BCL10 nuclear expression and interphase fluorescence in situ hybridization (FISH) for MALT1 and API2/MALT1 were tested. Thirteen out of the 22 cases (59.1%) achieved complete regression (CR) after the eradication of H. pylori. The longest follow-up period in the 22 patients was 68 months, with 12 patients longer than 24 months. For the 13 CR patients, the longest follow-up period after H. pylori eradication was 53 months, with 6 patients longer than 24 months. BCL10 nuclear expression was detected by immunohistochemical staining in 9 cases, including 7 (77.8%) of 9 cases who showed no response (NR) and 2 (15.4%) of 13 patients who achieved CR following eradication therapy (P < 0.05). t(11;18)(q21;q21) was evaluated by interphase FISH in 18 cases including 11 CR and 7 NR patients after H. pylori eradication. t(11;18)(q21;q21) was found in 4 (57.1%) of 7 patients who showed NR following H. pylori eradication, but one in 11 CR patients (P < 0.05). A total of 59.1% of patients with early gastric MALT lymphoma recruited in this study achieved CR after H. pylori eradication. BCL10 nuclear expression and t(11;18)(q21;q21)-positive gastric MALT lymphomas are likely to be related to a failure to respond to H. pylori eradication in Chinese patients.

Indexed as

Gene Expression Regulation, NeoplasticHelicobacter pyloriAdaptor Proteins, Signal TransducingAdolescentAdultAgedAnti-Bacterial AgentsAsian PeopleB-Cell CLL-Lymphoma 10 ProteinChinaChromosomes, Human, Pair 11Chromosomes, Human, Pair 18FemaleFollow-Up StudiesHelicobacter InfectionsHumansAdaptor Proteins, Signal TransducingAnti-Bacterial AgentsB-Cell CLL-Lymphoma 10 ProteinBCL10 protein, human

Identifiers

PMID18949449

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.