ArticleThe open cardiovascular medicine journal2008
Oxidative stress as a common mediator for apoptosis induced-cardiac damage in diabetic rats.
Article in The open cardiovascular medicine journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
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- Isolinderalactone Induces Cell Death via Mitochondrial Superoxide- and STAT3-Mediated Pathways in Human Ovarian Cancer Cells.International journal of molecular sciences · 2020Article
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health.Oxidative medicine and cellular longevity · 2019Review
- Retinol palmitate protects against myocardial ischemia/reperfusion injury via reducing oxidative stress and inhibiting apoptosis.American journal of translational research · 2019Article
- Wider perioperative glycemic fluctuations increase risk of postoperative atrial fibrillation and ICU length of stay.PloS one · 2018Article
- Protection by Ethanolic Extract fromThe Malaysian journal of medical sciences : MJMS · 2017Article
- MicroRNA-21 inhibits mitochondria-mediated apoptosis in keloid.Oncotarget · 2017Article
- Exercise Training Attenuates Upregulation of p47(phox) and p67(phox) in Hearts of Diabetic Rats.Oxidative medicine and cellular longevity · 2016Article
- Co-administration of Grape Seed Extract and Exercise Training Improves Endothelial Dysfunction of Coronary Vascular Bed of STZ-Induced Diabetic Rats.Iranian Red Crescent medical journal · 2013Article
- Putative free radical-scavenging activity of an extract of Cineraria maritima in preventing selenite-induced cataractogenesis in Wistar rat pups.Molecular vision · 2013Article
- Computer diagnosis in cardiology: oxidative stress hypothesis.North American journal of medical sciences · 2009Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the possible role of oxidative stress as a common mediator of apoptosis and cardiac damage in diabetes. MATERIALS AND
methodsThis experimental work was conducted on 5 groups of Wistar rats. Group I was the control group. Diabetes type 1 was induced in other groups (by streptozotocin) and animals received insulin or vitamin E (300 mg /kg body weight), both insulin and vitamin E, or no treatment for 4 weeks according to their group. At the end of the study, serum and cardiac tissues were examined for biochemical parameters of cardiac function, oxidative stress and apoptosis. Electron microscopy pictures of cardiac tissue were also evaluated for signs of cardiac damage
resultsMarkers of oxidative stress, apoptosis, inflammation as well as manifestations of cardiac damage as assessed by electron microscopy were significantly decreased in rats treated with both insulin and vitamin E when compared with untreated diabetic rats or rats treated with either insulin or vitamin E alone
conclusionAdministration of both vitamin E and insulin was effective in reducing markers of oxidative stress and apoptosis and improving parameters of cardiac function in experiments animals. Antioxidants might prove beneficial as an adjuvant treatment in addition to insulin in type 1 diabetes associated with manifestations of cardiac complications.
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