ArticleMolecular vision2008
The flavonoid, fisetin, inhibits UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells.
Article in Molecular vision, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- From Plant Chemistry to Reproducible Antidiabetic Products: A Critical Review of Molecular Targets, Clinical Evidence, and Translational Gaps.Molecules (Basel, Switzerland) · 2026Review
- Mannosylated fisetin/carveol lipid nanocapsules: brain-targeted dual therapy for modulation of epileptogenesis and cognitive deficits.Drug delivery and translational research · 2026Article
- Fisetin: a multitarget flavonol bridging oxidative stress, inflammation, aging, and cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Cellular Senescence in Health, Disease, and Lens Aging.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Fisetin Inhibits UVA-Induced Expression of MMP-1 and MMP-3 through the NOX/ROS/MAPK Pathway in Human Dermal Fibroblasts and Human Epidermal Keratinocytes.International journal of molecular sciences · 2023Article
- Review
- Fisetin Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Macrophage.BioMed research international · 2021Article
- Retracted Article: Structural characterization of peptides fromRSC advances · 2019Article
- Fisetin inhibits the growth and migration in the A549 human lung cancer cell line via the ERK1/2 pathway.Experimental and therapeutic medicine · 2018Article
- Ghrelin Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Damage.Oxidative medicine and cellular longevity · 2017Article
- Protective effects of appropriate Zn(2+) levels against UVB radiation-induced damage in human lens epithelial cells in vitro.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016Article
- Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway.Oxidative medicine and cellular longevity · 2016Article
- Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice.International ophthalmology · 2015Article
- Plants used in the management of diabetic complications.Indian journal of pharmaceutical sciences · 2014Review
- Article
- Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens.Journal of cellular and molecular medicine · 2013Article
- Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract.Interdisciplinary toxicology · 2011Article
- Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line.Evidence-based complementary and alternative medicine : eCAM · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeUltraviolet (UV) radiation-induced oxidative stress plays a significant role in the progression of cataracts. This study investigated the photoprotective effect of fisetin on UV radiation-induced oxidative stress in human lens epithelial cells and the possible molecular mechanism involved.
methodsSRA01/04 cells exposed to different doses of ultraviolet B (UVB) were cultured with various concentrations of fisetin and subsequently monitored for cell viability by the 4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT) assay. The effect of fisetin on the generation of reactive oxygen species (ROS) of SRA01/04 cells was determined by flow cytometry. Translocation of nuclear factor kappa-B (NF-kappaB) was examined by immunocytochemistry. Expression of NF-kappaB/P65, inhibiter kappa B (IkappaB), and mitogen activated protein kinase (MAPK) proteins were measured by western blot.
resultsTreatment of SRA01/04 cells with fisetin inhibited UVB-induced cell death and the generation of ROS. Fisetin inhibited UVB-induced activation and translocation of NF-kappaB/p65, which was mediated through an inhibition of the degradation and activation of IkappaB. Fisetin also inhibited UVB-induced phosphorylation of the p38 and c-Jun N-terminal kinase (JNK) proteins of the MAPK family at various time points studied.
conclusionsThe flavonoid, fisetin, could be useful in attenuation of UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells, which suggests that fisetin has a potential protective effect against cataractogenesis.
Indexed as
Identifiers
18949064PMC2571947W2158158765What OpenQuestion holds
Registered trials
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