ArticleMolecular vision2008
Increased SPARC expression in primary angle closure glaucoma iris.
Article in Molecular vision, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Associations of static and dynamic iris parameters in healthy Chinese individuals: the Handan Eye Study.Eye (London, England) · 2024Article
- SPARC: a potential target for functional nanomaterials and drugs.Frontiers in molecular biosciences · 2023Review
- Corvis Biomechanical Factor Facilitates the Detection of Primary Angle Closure Glaucoma.Translational vision science & technology · 2022Article
- Downregulation of secreted protein acidic and rich in cysteine in human trabecular meshwork cells.Experimental and therapeutic medicine · 2021Article
- Altered Iris Aquaporin Expression and Aqueous Humor Osmolality in Glaucoma.Investigative ophthalmology & visual science · 2021Article
- Updates on Genes and Genetic Mechanisms Implicated in Primary Angle-Closure Glaucoma.The application of clinical genetics · 2021Review
- Correlation of iris collagen andIndian journal of ophthalmology · 2019Article
- The SPARC-related modular calcium binding protein 2 (Clinical ophthalmology (Auckland, N.Z.) · 2017Article
- Distinct iris gene expression profiles of primary angle closure glaucoma and primary open angle glaucoma and their interaction with ocular biometric parameters.Clinical & experimental ophthalmology · 2016Article
- The genetic mechanisms of primary angle closure glaucoma.Eye (London, England) · 2015Review
- The Thrombospondin1-TGF-β Pathway and Glaucoma.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2015Article
- Anterior segment changes after pharmacologic mydriasis using Pentacam and optical coherence tomography in angle closure suspects.International journal of ophthalmology · 2015Article
- Comparison of anterior segment morphology following prophylactic laser peripheral iridotomy in Caucasian and Chinese eyes.Clinical & experimental ophthalmology · 2014Article
- Matrix metalloproteinases and tissue inhibitors of metalloproteinases in the aqueous humour of patients with primary angle closure glaucoma - a quantitative study.BMC ophthalmology · 2014Article
- Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment.Eye (London, England) · 2012Review
- Substratum stiffness and latrunculin B regulate matrix gene and protein expression in human trabecular meshwork cells.Investigative ophthalmology & visual science · 2012Article
- Mutational screening of VSX1, SPARC, SOD1, LOX, and TIMP3 in keratoconus.Molecular vision · 2011Article
- Susceptibility to primary angle closure glaucoma in Saudi Arabia: the possible role of mitochondrial DNA ancestry informative haplogroups.Molecular vision · 2011Article
- Evaluation of SPARC as a candidate gene of juvenile-onset primary open-angle glaucoma by mutation and copy number analyses.Molecular vision · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSPARC (secreted protein, acidic, and rich in cysteine) is involved in extracellular matrix (ECM) organization. The purpose of this study was to evaluate the expression of SPARC in iris tissue from primary angle closure glaucoma (PACG) eyes.
methodsIris tissue was obtained from peripheral iridectomies performed during trabeculectomy surgery in nine PACG and 16 primary open-angle glaucoma (POAG) eyes at the Singapore National Eye Centre. Three non-glaucoma control iris specimens were obtained from patients who underwent Descemet's stripping automated endothelial keratoplasty (DSAEK) procedure. SPARC and collagen I expression were quantified by real-time polymerase chain reaction (PCR). The histological distribution of collagen I and III in the iris stroma was determined using picrosirius red polarization. Density of the iris stromal vasculature was also calculated.
resultsThe mean age was 68.9+/-10.9 years and 65.7+/-12.2 years in POAG and PACG groups, respectively. The PACG iris expressed SPARC 13.6-fold more and collagen I 5.2 fold more compared to non-glaucoma control iris. The PACG iris also demonstrated 3.3 fold higher SPARC and 2.0 fold higher collagen I expression relative to the POAG iris. The density of collagen I was greater in PACG eyes than in POAG and control eyes (p<0.001). The mean density of iris stromal blood vessels per micron square area was similar in all three groups.
conclusionsSPARC was significantly increased in the PACG iris. The data suggest that SPARC could play a role in the development of PACG by influencing the biomechanical properties of the iris through a change in ECM organization.
Indexed as
Identifiers
18949063PMC2571946W2151897664What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.