ArticleMediators of inflammation2008
Association of single nucleotide polymorphisms in the IL-18 gene with production of IL-18 protein by mononuclear cells from healthy donors.
Article in Mediators of inflammation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- IL-18 polymorphisms and tuberculosis susceptibility: a meta-analysis.African health sciences · 2019Pooled it
- Association of IL-18 promoter gene polymorphisms with rheumatoid arthritis: a meta-analysis.Molecular biology reports · 2014Pooled it
- Association of polymorphisms in interleukin-18 and interleukin-28B genes with outcomes of hepatitis B virus infections: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Interleukin 18 and coronary heart disease: prospective study and systematic review.Atherosclerosis · 2011Pooled it
- Association between interleukin-18 promoter variants and tacrolimus pharmacokinetics in Chinese renal transplant patients.European journal of clinical pharmacology · 2015Trial
- Evaluating Single-Nucleotide Polymorphisms in Inflammasome Proteins and Serum Levels of IL-18 and IL-1β in Kidney Interstitial Damage in Anti-Neutrophilic Cytoplasmic Antibody-Associated Vasculitis.International journal of molecular sciences · 2024Article
- The Impact of Functional Promoter Variants in Interleukin-18 on Susceptibility to Rheumatoid Arthritis in Iranian Population.Advanced biomedical research · 2024Article
- Association of interleukin-18 genotypes (-607C > A) and (-137 G > C) with the hepatitis B virus disease progression to hepatocellular carcinoma.Molecular and cellular biochemistry · 2021Article
- Interleukin-18 and interferon-γ single nucleotide polymorphisms in Egyptian patients with tuberculosis.PloS one · 2021Article
- Interleukin-18 in Health and Disease.International journal of molecular sciences · 2019Review
- Genetic association of interleukin 18 (-607C/A, rs1946518) single nucleotide polymorphism with asthmatic children, disease severity and total IgE serum level.Central-European journal of immunology · 2019Article
- Hepatitis-related hepatocellular carcinoma: Insights into cytokine gene polymorphisms.World journal of gastroenterology · 2016Review
- Genetic variant in interleukin-18 is associated with idiopathic recurrent miscarriage in Chinese Han population.International journal of molecular sciences · 2015Article
- Interleukin-18 -607C/A gene polymorphism in Egyptian asthmatic children.Molecular diagnosis & therapy · 2014Article
- Interleukin 18 gene promoter polymorphisms and susceptibility to chronic hepatitis B infection: a review study.Hepatitis monthly · 2014Review
- Polymorphisms in the tumor necrosis factor receptor genes affect the expression levels of membrane-bound type I and type II receptors.Mediators of inflammation · 2014Article
- Correlation between interleukin-18 promoter -607C/A polymorphism and susceptibility to ischemic stroke.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Effect of interleukin-18 gene polymorphisms on sensitization to wheat flour in bakery workers.Journal of Korean medical science · 2012Article
- Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population.Hepatitis monthly · 2011Article
- Association of cytokine gene alleles with the inflammation of human periodontal tissue.Acta naturae · 2011Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IL-18 has proinflammatory effects and participates in both innate and adaptive cellular and humoral immunity. A number of SNPs that influence IL-18 production are found in the gene promoter region. We investigated the association of SNPs in the IL-18 promoter at -607 and -137 with the level of IL-18 protein production by PBMC from healthy donors from Southwestern Siberia. The genetic distribution of these SNPs in the promoter site was established by PCR. IL-18 protein production was determined by ELISA. Our results showed that PBMC from donors carrying allele 137C have lower levels of both spontaneous and LPS-stimulated IL-18 production. In contrast, PBMC from donors carrying allele 607A showed significant increases in spontaneous and stimulated IL-18 production compared to wild type. Our study suggests that the SNPs -607 and -137 in the promoter region of the IL-18 gene influence the level of IL-18 protein production by PBMC from healthy donors in Southwestern Siberia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.