ArticlePloS one2008
Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Leveraging Northern European population history: novel low-frequency variants for polycystic ovary syndrome.Human reproduction (Oxford, England) · 2022Pooled it
- Trial
- Population genomics, demography, and circum-Baltic connectivity of Early Medieval southwestern Finland.Genome biology · 2026Article
- Article
- Genetic predisposition to longer lifespan, lifestyle factors, and all-cause mortality: a 17-year prospective cohort study.GeroScience · 2026Article
- Systemic Disease Associations of Oral Lichenoid Disease: A Retrospective Case-Control Study.Oral diseases · 2026Article
- Better perceived health among the Swedish-speaking minority as compared with the Finnish-speaking majority in Finland: a cross-sectional study with an intergenerational perspective.Scandinavian journal of public health · 2025Article
- Y chromosome sequencing data suggest dual paths of haplogroup N1a1 into Finland.European journal of human genetics : EJHG · 2025Article
- Identification and functional characterisation of DNA methylation differences between East- and West-originating Finns.Epigenetics · 2024Article
- Blood donor biobank as a resource in personalised biomedical genetic research.European journal of human genetics : EJHG · 2024Article
- Decoding Genetics, Ancestry, and Geospatial Context for Precision Health.medRxiv : the preprint server for health sciences · 2023Article
- Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do.Journal of clinical medicine · 2023Review
- The genetic structure of Norway.European journal of human genetics : EJHG · 2021Article
- Genotypes of informative loci from 1000 Genomes data allude evolution and mixing of human populations.Scientific reports · 2021Article
- Changes in the fine-scale genetic structure of Finland through the 20th century.PLoS genetics · 2021Article
- Increasing accuracy of HLA imputation by a population-specific reference panel in a FinnGen biobank cohort.NAR genomics and bioinformatics · 2020Article
- Forensic psychiatry in Finland: an overview of past, present and future.International journal of mental health systems · 2020Review
- Human mitochondrial DNA lineages in Iron-Age Fennoscandia suggest incipient admixture and eastern introduction of farming-related maternal ancestry.Scientific reports · 2019Article
- Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland.American journal of human genetics · 2019Article
- Discovering heritable modes of MEG spectral power.Human brain mapping · 2019Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundGenome-wide data provide a powerful tool for inferring patterns of genetic variation and structure of human populations. PRINCIPAL
findingsIn this study, we analysed almost 250,000 SNPs from a total of 945 samples from Eastern and Western Finland, Sweden, Northern Germany and Great Britain complemented with HapMap data. Small but statistically significant differences were observed between the European populations (F(ST) = 0.0040, p<10(-4)), also between Eastern and Western Finland (F(ST) = 0.0032, p<10(-3)). The latter indicated the existence of a relatively strong autosomal substructure within the country, similar to that observed earlier with smaller numbers of markers. The Germans and British were less differentiated than the Swedes, Western Finns and especially the Eastern Finns who also showed other signs of genetic drift. This is likely caused by the later founding of the northern populations, together with subsequent founder and bottleneck effects, and a smaller population size. Furthermore, our data suggest a small eastern contribution among the Finns, consistent with the historical and linguistic background of the population. SIGNIFICANCE: Our results warn against a priori assumptions of homogeneity among Finns and other seemingly isolated populations. Thus, in association studies in such populations, additional caution for population structure may be necessary. Our results illustrate that population history is often important for patterns of genetic variation, and that the analysis of hundreds of thousands of SNPs provides high resolution also for population genetics.
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