ArticlePLoS computational biology2008
Fusion and fission of genes define a metric between fungal genomes.
Article in PLoS computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
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- Cryogenian Origin and Subsequent Diversification of the Plant Cell-Wall Enzyme XTH Family.Plant & cell physiology · 2021Article
- The relationship between chimeric RNAs and gene fusions: Potential implications of reciprocity in cancer.Journal of genetics and genomics = Yi chuan xue bao · 2020Article
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- Comparative Analysis of Type IV Pilin inFrontiers in microbiology · 2016Article
- The Recent De Novo Origin of Protein C-Termini.Genome biology and evolution · 2015Article
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- A pluralistic account of homology: adapting the models to the data.Molecular biology and evolution · 2014Review
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- Evolution of saxitoxin synthesis in cyanobacteria and dinoflagellates.Molecular biology and evolution · 2013Article
- Evolution at the subgene level: domain rearrangements in the Drosophila phylogeny.Molecular biology and evolution · 2012Article
- Split-Doa10: a naturally split polytopic eukaryotic membrane protein generated by fission of a nuclear gene.PloS one · 2012Article
- Protein functional links in Trypanosoma brucei, identified by gene fusion analysis.BMC evolutionary biology · 2011Article
- Yeast evolutionary genomics.Nature reviews. Genetics · 2010Review
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- Génolevures: protein families and synteny among complete hemiascomycetous yeast proteomes and genomes.Nucleic acids research · 2009Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene fusion and fission events are key mechanisms in the evolution of gene architecture, whose effects are visible in protein architecture when they occur in coding sequences. Until now, the detection of fusion and fission events has been performed at the level of protein sequences with a post facto removal of supernumerary links due to paralogy, and often did not include looking for events defined only in single genomes. We propose a method for the detection of these events, defined on groups of paralogs to compensate for the gene redundancy of eukaryotic genomes, and apply it to the proteomes of 12 fungal species. We collected an inventory of 1,680 elementary fusion and fission events. In half the cases, both composite and element genes are found in the same species. Per-species counts of events correlate with the species genome size, suggesting a random mechanism of occurrence. Some biological functions of the genes involved in fusion and fission events are slightly over- or under-represented. As already noted in previous studies, the genes involved in an event tend to belong to the same functional category. We inferred the position of each event in the evolution tree of the 12 fungal species. The event localization counts for all the segments of the tree provide a metric that depicts the "recombinational" phylogeny among fungi. A possible interpretation of this metric as distance in adaptation space is proposed.
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