ArticleAnnals of surgery2008
Intestinal specific overexpression of interleukin-7 attenuates the alternation of intestinal intraepithelial lymphocytes after total parenteral nutrition administration.
Article in Annals of surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Keratinocytes regulate intraepithelial lymphocytes homing and mediate mucosal barrier integrity via JAK2/STAT3 signaling in oral lichen planus.Frontiers in immunology · 2026Article
- Intestinal Epithelial Cells-Derived Hypoxia-Inducible Factor-1α Is Essential for the Homeostasis of Intestinal Intraepithelial Lymphocytes.Frontiers in immunology · 2019Article
- The interplay of BMP4 and IL‑7 regulates the apoptosis of intestinal intraepithelial lymphocytes under conditions of ischemia̸reperfusion.International journal of molecular medicine · 2018Article
- Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.Scientific reports · 2016Article
- CD8αα TCRαβ Intraepithelial Lymphocytes in the Mouse Gut.Digestive diseases and sciences · 2016Review
- Homeostasis alteration within small intestinal mucosa after acute enteral refeeding in total parenteral nutrition mouse model.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Aryl Hydrocarbon Receptor Activation Down-Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS-Induced Colitis.Digestive diseases and sciences · 2015Article
- Enteral nutrient deprivation in patients leads to a loss of intestinal epithelial barrier function.Surgery · 2015Article
- Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Disturbance of intraepithelial lymphocytes in a murine model of acute intestinal ischemia/reperfusion.Journal of molecular histology · 2014Article
- Total parenteral nutrition-associated lamina propria inflammation in mice is mediated by a MyD88-dependent mechanism.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Changes in morphology and function in small intestinal mucosa after Roux-en-Y surgery in a rat model.The Journal of surgical research · 2012Article
- Epidermal growth factor/TNF-α transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo.International journal of clinical and experimental pathology · 2012Article
- Glutamine prevents total parenteral nutrition-associated changes to intraepithelial lymphocyte phenotype and function: a potential mechanism for the preservation of epithelial barrier function.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTotal parenteral nutrition (TPN), with the complete removal of enteral nutrition, results in marked changes in intestinal intraepithelial lymphocyte (IEL) function and phenotype. Previous work shows that TPN results in a loss of intestinal epithelial cell-derived interleukin-7 (IL-7), and this loss may play an important role in development of such TPN-associated IEL changes.
methodsTo further understand this relation, we generated a transgenic mouse (IL-7), which overexpresses IL-7 specifically in intestinal epithelial cells. We hypothesized that this localized overexpression would attenuate many of the observed TPN-associated IEL changes.
resultsOur study showed that TPN administration led to significant changes in IEL phenotype, including a marked decline in the CD8alphabeta+, CD4+, and alphabeta-TCR+ populations. IEL basal proliferation decreased 1.7-fold compared with wild-type TPN mice. TPN administration in wild-type mice resulted in several changes in IEL-derived cytokine expression. IL-7 mice given TPN, however, maintained IEL proliferation, and sustained normal IEL numbers and phenotype.
conclusionsWe conclude that specific intestinal IL-7 overexpression significantly attenuated many IEL changes in phenotype and function after TPN administration. These findings suggest a mechanism by which TPN results in observed IEL changes.
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