Evidence map›Paper›PMID 18948711›Full record

ReviewGenome dynamics2009

Variation in patterns of human meiotic recombination.

P P Khil, R D Camerini-Otero

Open access · greenAbstract readReview
In one paragraph

Review in Genome dynamics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

P P KhilGenetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, Md., USA.
R D Camerini-Otero
National Institutes of Health · US

Funding

What determines the location of meiotic crossovers in the mammalian genome?ZIADK052034 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CAMERINI-OTERO, RAFAEL · 2009 to 2025
$29.8M
What determines the location of meiotic crossovers in the mammalian genome?Z01DK052034 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CAMERINI-OTERO, RAFAEL · 2007 to 2008
$650k
Intramural NIH HHS Z01 DK052034Intramural NIH HHS Z99 DK999999
6 · The paper itself

Abstract

In the last 30 years it has become evident that patterns of meiotic recombination can be highly variable among individuals. The evidence comes from both low and high resolution analyses of hotspots of recombination in human and other species. In addition, a comparison of the recombination profiles in closely related species such as human and chimpanzee reveals essentially no correlation in the position of hotspots. Although the variation in hotspots of meiotic recombination is clearly documented, the mechanisms responsible for such variation are far from being understood. Here we will review the available evidence of natural variation in meiotic recombination and will discuss potential implications of this variation on the functional mechanisms of crossover formation and control.

Indexed as

Genetic VariationMeiosisComputational BiologyHumansRecombination, Genetic

Identifiers

PMID18948711
PMCPMC3105470
OpenAlexW1560440523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.