ArticleStroke2009
Genome screen to detect linkage to common susceptibility genes for intracranial and aortic aneurysms.
Article in Stroke, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of Intracranial Aneurysm in Patients with Aortopathy: A Systematic Review with Meta-Analyses.Journal of stroke · 2020Pooled it
- Whole Exome Sequencing in Patients with Phenotypically Associated Familial Intracranial Aneurysm.Korean journal of radiology · 2022Article
- Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.Journal of the American Heart Association · 2016Article
- Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm.PloS one · 2015Article
- Anterior cerebral artery aneurysm associated with multiple intracranial aneurysms and abdominal aorta aneurysm.Anatomy & cell biology · 2013Article
- A balanced translocation truncates Neurotrimin in a family with intracranial and thoracic aortic aneurysm.Journal of medical genetics · 2012Article
- Diagnosis and monitoring of abdominal aortic aneurysm: current status and future prospects.Current problems in cardiology · 2010Review
- Spontaneous arterial dissection: phenotype and molecular pathogenesis.Cellular and molecular life sciences : CMLS · 2010Review
Corrections and comments
- Erratum issued
Authors and funding
14 authors.
Funding
Abstract
background and purposeRisk for both intracranial aneurysms (IAs) and aortic aneurysms (AAs) is thought to be heritable with mounting evidence for genetic predisposition. The concept of shared risk for these conditions is challenged by differences in age of diagnosis and demographic characteristics. We performed a genomewide linkage analysis in multiplex families with both IA and AA from the Familial Intracranial Aneurysm study.
methodsAvailable medical records of subjects who reported IA or abdominal/thoracic AA were reviewed with adjudication as definite/probable, possible, or not a case. To identify genes contributing to the susceptibility for IA and AA, genomewide linkage analysis was performed in the 26 multiplex IA families who had members who also had thoracic or abdominal AA. Individuals (n=91) were defined as affected if they had an IA (definite/probable) or an aortic or thoracic AA (definite/probable).
resultsMaximum logarithm of odds (LOD) scores were found on chromosomes 11 (144 cM; LOD=3.0) and 6 (33 cM; LOD=2.3). In both chromosomal regions, analyses of these same 26 families considering only IA as the disease phenotype produced LOD scores of 1.8 and 1.6, respectively.
conclusionsOur linkage analysis in these 26 families using the broadest disease phenotype, including IA, abdominal AA, and thoracic AA, supports the concept of shared genetic risk. The chromosome 11 locus appears to confirm earlier independent associations in IA and AA. The chromosome 6 finding is novel. Both warrant further investigation.
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