ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2008
Cumulative deficits and physiological indices as predictors of mortality and long life.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03574662 (A Prospective Trial to Evaluate the Utility of Focused Frailty Interventions on Patients With Advanced Heart Failure), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Trial to Evaluate the Utility of Focused Frailty Interventions on Patients With Advanced Heart Failure
Who cites it
29 citing papers in PubMed.
- Trial
- Association of Number of Comorbid Conditions and Pain among United States Adults.Diseases (Basel, Switzerland) · 2024Article
- The Longitudinal Relationship between Frailty, Loneliness and Cardiovascular Disease: A Prospective Cohort Study.The journal of nutrition, health & aging · 2023Article
- Aging, frailty, and design of built environments.Journal of physiological anthropology · 2022Review
- Frailty and Biological Age.Annals of geriatric medicine and research · 2021Article
- Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study.Frontiers in public health · 2020Article
- The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study.BMC medicine · 2019Article
- Associations between a laboratory frailty index and adverse health outcomes across age and sex.Aging medicine (Milton (N.S.W)) · 2019Article
- Frailty Is Predictive of Adverse Postoperative Events in Patients Undergoing Lumbar Fusion.Global spine journal · 2017Article
- APOE gene polymorphism in long-lived individuals from a central China population.Scientific reports · 2017Article
- Frailty for Surgeons: Review of a National Institute on Aging Conference on Frailty for Specialists.Journal of the American College of Surgeons · 2015Review
- Age-related frailty and its association with biological markers of ageing.BMC medicine · 2015Article
- Frailty in the Honolulu-Asia Aging Study: deficit accumulation in a male cohort followed to 90% mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Social vulnerability from a social ecology perspective: a cohort study of older adults from the National Population Health Survey of Canada.BMC geriatrics · 2014Article
- Frailty and outcomes after implantation of left ventricular assist device as destination therapy.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2014Article
- Joint Analyses of Longitudinal and Time-to-Event Data in Research on Aging: Implications for Predicting Health and Survival.Frontiers in public health · 2014Review
- Association of healthy aging with parental longevity.Age (Dordrecht, Netherlands) · 2013Article
- Unraveling genetic origin of aging-related traits: evolving concepts.Rejuvenation research · 2013Review
- Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age?The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Constructing an index of physical fitness age for Japanese elderly based on 7-year longitudinal data: sex differences in estimated physical fitness age.Age (Dordrecht, Netherlands) · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We evaluated the predictive potential for long-term (24-year) survival and longevity (85+ years) of an index of cumulative deficits (DI) and six physiological indices (pulse pressure, diastolic blood pressure, pulse rate, serum cholesterol, blood glucose, and hematocrit) measured in mid- to late life (44-88 years) for participants of the 9th and 14th Framingham Heart Study examinations. For all ages combined, the DI, pulse pressure, and blood glucose are the strongest determinants of both long-term survival and longevity, contributing cumulatively to their explanation. Diastolic blood pressure and hematocrit are less significant determinants of both of these outcomes. The pulse rate is more relevant to survival, whereas serum cholesterol is more relevant to longevity. Only the DI is a significant predictor of longevity and mortality for each 5-year age group ranging from 45 to 85 years. The DI appears to be a more important determinant of long-term risks of death and longevity than are the physiological indices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.