ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2008
Aging-dependent regulation of antioxidant enzymes and redox status in chronically loaded rat dorsiflexor muscles.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
- Plasma proteomic analysis of stable coronary artery disease indicates impairment of reverse cholesterol pathway.Scientific reports · 2016Trial
- Inter-Organ Crosstalk and Regulatory Mechanisms of Skeletal Muscle-Derived Extracellular Vesicles in Systemic Metabolic Homeostasis.Journal of cellular and molecular medicine · 2025Review
- Skeletal Muscle Aging: Enhancing Skeletal Muscle Integrity and Function as a Potential Pharmacological Approach.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Branched-chain amino acids and L-alanine supplementation ameliorate calcium dyshomeostasis in sarcopenia: New insights for nutritional interventions.Frontiers in pharmacology · 2024Article
- The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults.Redox biology · 2023Article
- Effects of Resistance Training on the Redox Status of Skeletal Muscle in Older Adults.Antioxidants (Basel, Switzerland) · 2021Article
- Muscle-derived exosomes encapsulate myomiRs and are involved in local skeletal muscle tissue communication.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Age-dependent stress response DNA demethylation and gene upregulation accompany nuclear and skeletal muscle remodeling following acute resistance-type exercise in rats.Facets (Ottawa) · 2020Article
- Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal MushroomNutrients · 2019Article
- Age-related changes in skeletal muscle: changes to life-style as a therapy.Biogerontology · 2018Review
- Enhancement of Skeletal Muscle in Aged Rats Following High-Intensity Stretch-Shortening Contraction Training.Rejuvenation research · 2017Article
- Mitochondria Initiate and Regulate Sarcopenia.Exercise and sport sciences reviews · 2017Review
- Age-related alterations in the sarcolemmal environment are attenuated by lifelong caloric restriction and voluntary exercise.Experimental gerontology · 2016Article
- Age-dependent Muscle Adaptation after Chronic Stretch-shortening Contractions in Rats.Aging and disease · 2016Article
- A preliminary study on the effects of star fruit consumption on antioxidant and lipid status in elderly Thai individuals.Clinical interventions in aging · 2016Article
- The effects of buthionine sulfoximine treatment on diaphragm contractility and SERCA pump function in adult and middle aged rats.Physiological reports · 2015Article
- Mechanistic Hierarchical Gaussian Processes.Journal of the American Statistical Association · 2014Article
- Epigallocatechin-3-gallate improves plantaris muscle recovery after disuse in aged rats.Experimental gerontology · 2014Article
- Magnetic resonance imaging of graded skeletal muscle injury in live rats.Environmental health insights · 2014Article
- Elevated hydrogen peroxide and decreased catalase and glutathione peroxidase protection are associated with aging sarcopenia.BMC geriatrics · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
This study compares changes in the pro-oxidant production and buffering capacity in young and aged skeletal muscle after exposure to chronic repetitive loading (RL). The dorsiflexors from one limb of young and aged rats were loaded 3 times/week for 4.5 weeks using 80 maximal stretch-shortening contractions per session. RL increased H2O2 in tibialis anterior muscles of young and aged rats and decreased the ratio of reduced/oxidized glutathione and lipid peroxidation in aged but not young adult animals. Glutathione peroxidase (GPx) activity decreased whereas catalase activity increased with RL in muscles from young and aged rats. RL increased CuZn superoxide disumutase (SOD) and Mn SOD protein concentration and CuZn SOD activity in muscles from young but not aged animals. There were no changes in protein content for GPx-1 and catalase or messenger RNA for any of the enzymes studied. These data show that aging reduces the adaptive capacity of muscles to buffer increased pro-oxidants imposed by chronic RL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.