ArticleDevelopment (Cambridge, England)2008
Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm.
Article in Development (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Bmp16 Regulates Arterial Valve Morphogenesis Through Modulation of Notch Signaling in Zebrafish.International journal of molecular sciences · 2026Article
- Organizers in a dish: Modeling human CNS morphogenesis.Developmental cell · 2026Review
- BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates.The EMBO journal · 2026Article
- Formation control between leader and migratory follower tissues allows coordinated growth.Science advances · 2025Article
- Neural plate pre-patterning enables specification of intermediate neural progenitors in the spinal cord.bioRxiv : the preprint server for biology · 2025Article
- Evolutionary Insights into Muscle Fiber Distribution in the Twin Tails of Ornamental Goldfish.Zoological studies · 2025Article
- Follistatin like-1 (Adipocyte · 2024Article
- Mesoderm induction and patterning: Insights from neuromesodermal progenitors.Seminars in cell & developmental biology · 2022Review
- Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants.Arthritis research & therapy · 2021Article
- Article
- FSTL1 suppresses tumor cell proliferation, invasion and survival in non-small cell lung cancer.Oncology reports · 2018Article
- Epigenetic inactivation of follistatin-like 1 mediates tumor immune evasion in nasopharyngeal carcinoma.Oncotarget · 2016Article
- Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma.Journal of hematology & oncology · 2015Article
- Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes.American journal of physiology. Heart and circulatory physiology · 2013Article
- The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands.Developmental biology · 2013Article
- Article
- BMP and non-canonical Wnt signaling are required for inhibition of secondary tail formation in zebrafish.Development (Cambridge, England) · 2011Article
- Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis.PloS one · 2011Article
- Downregulated expression of the secreted glycoprotein follistatin-like 1 (Fstl1) is a robust hallmark of preadipocyte to adipocyte conversion.Mechanisms of development · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In zebrafish, BMP signaling establishes cell identity along the dorsoventral (DV) axis during gastrulation. Owing to the early requirements of BMP activity in DV patterning, it has been difficult to assign later roles in cell fate specification to specific BMP ligands. In this study, we have taken advantage of two follistatin-like genes (fstl1 and fstl2), as well as a transgenic zebrafish line carrying an inducible truncated form of the BMP-type 1 receptor to study the role of Bmp4 outside of the context of DV specification. Characterization of fstl1/2 suggests that they exert a redundant role as BMP antagonists during late gastrulation, regulating BMP activity in axial mesoderm. Maintenance of appropriate levels of BMP signaling is crucial for the proper development of chordamesoderm, a subset of axial mesoderm that gives rise to the notochord, but not prechordal mesoderm, which gives rise to the prechordal plate. Bmp4 activity in particular is required during a crucial window beginning at late gastrulation and lasting through early somitogenesis to promote chordamesoderm proliferation. In the absence of Bmp4, the notochord precursor pool is depleted, and the notochord differentiates prematurely. Our results illustrate a role for Bmp4 in the proliferation and timely differentiation of axial tissue after DV axis specification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.