ArticleEndocrinology2009
Facilitative glucose transporter type 1 is differentially regulated by progesterone and estrogen in murine and human endometrial stromal cells.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 100 citations in OpenAlex.
- Tiaojing Cuyun Recipe inhibits ferroptosis through SLC7A11/GSH/GPX4 axis to improve endometrial receptivity of mice with embryo implantation dysfunction.Journal of traditional and complementary medicine · 2026Article
- GSK3β-Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Regulatory Interplay of p53, AMPK, and mTOR in Decidualization: Implications for Reproductive Competence and Cancer Biology.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Glucose metabolism and endometrium decidualization.Frontiers in endocrinology · 2025Review
- Decidualized Endometrial Stromal Cells Promote Mitochondrial Beta-Oxidation to Produce the Octanoic Acid Required for Implantation.Biomolecules · 2024Article
- Metabolic reprogramming and heterogeneity during the decidualization process of endometrial stromal cells.Cell communication and signaling : CCS · 2024Article
- Article
- Differential gene expression in decidualized human endometrial stromal cells induced by different stimuli.Scientific reports · 2024Article
- Embryo-endometrial interaction associated with the location of the embryo during the mobility phase in mares.Scientific reports · 2024Article
- Take metabolic heterogeneity into consideration when applying dietary interventions to cancer therapy: A review.Heliyon · 2023Review
- Energy metabolism and maternal-fetal tolerance working in decidualization.Frontiers in immunology · 2023Review
- Glucose and fatty acids catabolism during in vitro decidualization of human endometrial stromal cells.Journal of assisted reproduction and genetics · 2022Article
- The Regulators of Human Endometrial Stromal Cell Decidualization.Biomolecules · 2022Review
- Developing dietary interventions as therapy for cancer.Nature reviews. Cancer · 2022Review
- Glucose transporters: Important regulators of endometrial cancer therapy sensitivity.Frontiers in oncology · 2022Review
- An appraisal of the current status of inhibition of glucose transporters as an emerging antineoplastic approach: Promising potential of new pan-GLUT inhibitors.Frontiers in pharmacology · 2022Review
- SLC2A12 of SLC2 Gene Family in Bird Provides Functional Compensation for the Loss of SLC2A4 Gene in Other Vertebrates.Molecular biology and evolution · 2021Article
- Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects ofFrontiers in neurology · 2021Article
- Endometrial Glucose Transporters in Health and Disease.Frontiers in cell and developmental biology · 2021Review
- Physiological and genetic convergence supports hypoxia resistance in high-altitude songbirds.PLoS genetics · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Embryo implantation is a highly synchronized event between an activated blastocyst and a receptive endometrium. The success of this process relies on the dynamic interplay of estrogen (E(2)) and progesterone (P(4)), however, the details of this interaction are not entirely clear. Recent data implicate E(2) and P(4) in the regulation of glucose utilization by affecting facilitative glucose transporter (GLUT) expression. In this study we examine GLUT1 expression in murine and human endometrial stromal cells (ESCs) using a primary culture system. We show that expression of GLUT1 is increased during ESC decidualization in vitro. P(4) up-regulates, whereas E(2) down-regulates, GLUT1 expression. In addition, P(4) increases and E(2) decreases glucose uptake in ESCs, suggesting that GLUT1 may be a major player in glucose utilization in these cells. Moreover, GLUT1 expression is increased in human ESCs when decidualized in vitro with P(4) and dibutyryl cAMP, suggesting a similar role for P(4) in human endometrium. In conclusion, an imbalance between P(4) and E(2) seen in patients with polycystic ovary syndrome, luteal phase defect, and recurrent pregnancy loss may have a critical impact on glucose utilization in the endometrial stroma, and, thus, may be responsible for endometrial dysfunction and failure of embryo implantation in these patient populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.