ArticleBMC plant biology2008
RACK1 genes regulate plant development with unequal genetic redundancy in Arabidopsis.
Article in BMC plant biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Systematic Review of Plant Ribosome Heterogeneity and Specialization.Frontiers in plant science · 2020Pooled it
- Stu-miR393-5p-StTIR1A-StPLC2 module regulates the development of adventitious and lateral roots of potato.Plant cell reports · 2026Article
- RACK1A interacts and colocalizes with FSD1 in stress granules to regulate salt stress response in Arabidopsis.Plant physiology · 2026Article
- RACK1A positively regulates opening of the apical hook inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The turnover of ABI5 by scaffold proteins to attenuate ABA signaling.Journal of experimental botany · 2024Article
- Molecular Cloning, Characterization, and Expression of a Receptor for Activated Protein Kinase C1 (RACK1) Gene inBiology · 2024Article
- Receptor for Activated C Kinase1B (RACK1B) Delays Salinity-Induced Senescence in Rice Leaves by Regulating Chlorophyll Degradation.Plants (Basel, Switzerland) · 2023Article
- Article
- Proteomic Profiling of Plant and Pathogen Interaction on the Leaf Epidermis.International journal of molecular sciences · 2022Article
- A comparative proteomics study of Arabidopsis thaliana responding to the coexistence of BPA and TiOEcotoxicology and environmental safety · 2022Article
- Receptor for Activated C Kinase1B (OsRACK1B) Impairs Fertility in Rice through NADPH-Dependent HInternational journal of molecular sciences · 2022Article
- Identification and validation of a locus for wheat maximum root length independent of parental reproductive environment.Frontiers in plant science · 2022Article
- A Conserved Long Intergenic Non-coding RNA Containing snoRNA Sequences,Frontiers in plant science · 2022Article
- A single-cell view of the transcriptome during lateral root initiation in Arabidopsis thaliana.The Plant cell · 2021Article
- Small compounds targeting tyrosine phosphorylation of Scaffold Protein Receptor for Activated C Kinase1A (RACK1A) regulate auxin mediated lateral root development inPlant signaling & behavior · 2021Article
- Phyllotaxis: from classical knowledge to molecular genetics.Journal of plant research · 2021Review
- Extraribosomal Functions of Cytosolic Ribosomal Proteins in Plants.Frontiers in plant science · 2021Review
- The composition and turnover of the Arabidopsis thaliana 80S cytosolic ribosome.The Biochemical journal · 2020Article
- Article
- The basic helix-loop-helix transcription factor OsBLR1 regulates leaf angle in rice via brassinosteroid signalling.Plant molecular biology · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRACK1 is a versatile scaffold protein in mammals, regulating diverse developmental processes. Unlike in non-plant organisms where RACK1 is encoded by a single gene, Arabidopsis genome contains three RACK1 homologous genes, designated as RACK1A, RACK1B and RACK1C, respectively. Previous studies indicated that the loss-of-function alleles of RACK1A displayed multiple defects in plant development. However, the functions of RACK1B and RACK1C remain elusive. Further, the relationships between three RACK1 homologous genes are unknown.
resultsWe isolated mutant alleles with loss-of-function mutations in RACK1B and RACK1C, and examined the impact of these mutations on plant development. We found that unlike in RACK1A, loss-of-function mutations in RACK1B or RACK1C do not confer apparent defects in plant development, including rosette leaf production and root development. Analyses of rack1a, rack1b and rack1c double and triple mutants, however, revealed that rack1b and rack1c can enhance the rack1a mutant's developmental defects, and an extreme developmental defect and lethality were observed in rack1a rack1b rack1c triple mutant. Complementation studies indicated that RACK1B and RACK1C are in principle functionally equivalent to RACK1A. Gene expression studies indicated that three RACK1 genes display similar expression patterns but are expressed at different levels. Further, RACK1 genes positively regulate each other's expression.
conclusionThese results suggested that RACK1 genes are critical regulators of plant development and that RACK1 genes function in an unequally redundant manner. Both the difference in RACK1 gene expression level and the cross-regulation are likely the molecular determinants of their unequal genetic redundancy.
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