ArticleJournal of nanobiotechnology2008
Toxicity of CdSe Nanoparticles in Caco-2 Cell Cultures.
Article in Journal of nanobiotechnology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.
- Meta-analysis of cellular toxicity for cadmium-containing quantum dots.Nature nanotechnology · 2016Pooled it
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- Safe nanomaterials: from their use, application, and disposal to regulations.Nanoscale advances · 2024Review
- Photoinduced Antibacterial Activity and Cytotoxicity of CdS Stabilized on Mesoporous Aluminosilicates and Silicates.Pharmaceutics · 2022Article
- Electrospun Cadmium Selenide Nanoparticles-Loaded Cellulose Acetate Fibers for Solar Thermal Application.Nanomaterials (Basel, Switzerland) · 2020Article
- Microphysiological Systems: Next Generation Systems for Assessing Toxicity and Therapeutic Effects of Nanomaterials.Small methods · 2020Article
- Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity.Nanomaterials (Basel, Switzerland) · 2018Review
- Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties.Nanoscale research letters · 2018Review
- Effects of food-borne nanomaterials on gastrointestinal tissues and microbiota.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018Review
- Three-photon imaging using defect-induced photoluminescence in biocompatible ZnO nanoparticles.International journal of nanomedicine · 2018Article
- The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group.Particle and fibre toxicology · 2017Review
- Review
- Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells.Frontiers in pharmacology · 2017Article
- Penetration of CdSe/ZnS quantum dots into differentiated vs undifferentiated Caco-2 cells.Journal of nanobiotechnology · 2016Article
- Direct quantification of rare earth doped titania nanoparticles in individual human cells.Nanotechnology · 2016Article
- Cytotoxicity investigation of luminescent nanohybrids based on chitosan and carboxymethyl chitosan conjugated with BiToxicology research · 2016Article
- Oxidative stress response in neural stem cells exposed to different superparamagnetic iron oxide nanoparticles.International journal of nanomedicine · 2016Article
- Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries.Mutagenesis · 2016Article
- Cell type-dependent changes in CdSe/ZnS quantum dot uptake and toxic endpoints.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPotential routes of nanomaterial exposure include inhalation, dermal contact, and ingestion. Toxicology of inhalation of ultra-fine particles has been extensively studied; however, risks of nanomaterial exposure via ingestion are currently almost unknown. Using enterocyte-like Caco-2 cells as a small intestine epithelial model, the possible toxicity of CdSe quantum dot (QD) exposure via ingestion was investigated. Effect of simulated gastric fluid treatment on CdSe QD cytotoxicity was also studied.
resultsCommercially available CdSe QDs, which have a ZnS shell and poly-ethylene glycol (PEG) coating, and in-house prepared surfactant coated CdSe QDs were dosed to Caco-2 cells. Cell viability and attachment were studied after 24 hours of incubation. It was found that cytotoxicity of CdSe QDs was modulated by surface coating, as PEG coated CdSe QDs had less of an effect on Caco-2 cell viability and attachment. Acid treatment increased the toxicity of PEG coated QDs, most likely due to damage or removal of the surface coating and exposure of CdSe core material. Incubation with un-dialyzed in-house prepared CdSe QD preparations, which contained an excess amount of free Cd2+, resulted in dramatically reduced cell viability.
conclusionExposure to CdSe QDs resulted in cultured intestinal cell detachment and death; cytotoxicity depended largely, however, on the QD coating and treatment (e.g. acid treatment, dialysis). Experimental results generally indicated that Caco-2 cell viability correlated with concentration of free Cd2+ ions present in cell culture medium. Exposure to low (gastric) pH affected cytotoxicity of CdSe QDs, indicating that route of exposure may be an important factor in QD cytotoxicity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.