Evidence map›Paper›PMID 18947260›Full record

SynthesisDrugs & aging2008

Update on oral cyanocobalamin (vitamin B12) treatment in elderly patients.

Emmanuel Andrès, Thomas Vogel, Laure Federici, Jacques Zimmer, Georges Kaltenbach

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Drugs & aging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Oral vitamin BThe Cochrane database of systematic reviews · 2018
    Pooled it
  2. Diagnostic value of oral "beefy red" patch in vitamin B12 deficiency.Therapeutics and clinical risk management · 2018
    Article
  3. Vitamin B12 deficit and development of geriatric syndromes.Colombia medica (Cali, Colombia) · 2013
    Article
  4. A short review of malabsorption and anemia.World journal of gastroenterology · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Emmanuel AndrèsDepartment of Internal Medicine, Diabetes and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. emmanuel.andres@chru-strasbourg.fr
Thomas Vogel
Laure Federici
Jacques Zimmer
Georges Kaltenbach
Hôpitaux Universitaires de Strasbourg · FRLaboratoire National de Santé · LU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a systematic review by the Cochrane group (n=1) and prospective studies in a well defined population (n=5) provide evidence that oral cobalamin therapy may adequately treat cobalamin deficiency in elderly patients. However, the current literature does not suggest a strategy in terms of the form (hydroxy- or cyanocobalamin), frequency and duration of the treatment. This review confirms the previously reported efficacy of oral cobalamin treatment in elderly patients. Oral cobalamin treatment avoids the discomfort, inconvenience and cost of monthly injections.

Indexed as

Dietary SupplementsAgedHumansRandomized Controlled Trials as TopicVitamin B 12Vitamin B 12 DeficiencyVitamin B 12

Identifiers

PMID18947260
OpenAlexW1971442375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.