ArticleCurrent microbiology2009
Identification of two multidrug-resistant Pseudomonas aeruginosa clonal lineages with a countrywide distribution in Hungary.
Article in Current microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Prioritization of Critical Factors for Surveillance of the Dissemination of Antibiotic Resistance inInternational journal of molecular sciences · 2023Pooled it
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- Detection of the ST111 Global High-RiskCurrent issues in molecular biology · 2025Article
- Antibiotic Resistance and Virulence Determinants ofMicroorganisms · 2025Article
- High-riskHeliyon · 2025Article
- Acquired antibiotic resistance ofAIMS microbiology · 2025Review
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- Molecular Typing ofDiagnostics (Basel, Switzerland) · 2024Article
- Detection of Acquired Antibiotic Resistance Genes in Domestic Pig (Antibiotics (Basel, Switzerland) · 2022Article
- Epidemiology and natural history ofERJ open research · 2018Article
- Genomic characterization of a local epidemicMicrobial genomics · 2017Article
- Determination of carbapenem resistance mechanism in clinical isolates of Pseudomonas aeruginosa isolated from burn patients, in Tehran, Iran.Journal of epidemiology and global health · 2017Article
- Resistance of Animal Strains ofFrontiers in microbiology · 2017Article
- Antibiotic Resistance Patterns and Genetic Diversity in Clinical Isolates of Pseudomonas aeruginosa Isolated From Patients of a Referral Hospital, Isfahan, Iran.Jundishapur journal of microbiology · 2015Article
- Clonal Relatedness among Imipenem-Resistant Pseudomonas aeruginosa Isolated from ICU-Hospitalized Patients.Critical care research and practice · 2015Article
- Extensively drug-resistant pseudomonas aeruginosa isolates containing blaVIM-2 and elements of Salmonella genomic island 2: a new genetic resistance determinant in Northeast Ohio.Antimicrobial agents and chemotherapy · 2014Article
- Population structure of clinical Pseudomonas aeruginosa from West and Central African countries.PloS one · 2014Article
- Rapid identification of international multidrug-resistant Pseudomonas aeruginosa clones by multiple-locus variable number of tandem repeats analysis and investigation of their susceptibility to lytic bacteriophages.Antimicrobial agents and chemotherapy · 2012Article
- Genetic markers of widespread extensively drug-resistant Pseudomonas aeruginosa high-risk clones.Antimicrobial agents and chemotherapy · 2012Article
- VIM-2-producing multidrug-resistant Pseudomonas aeruginosa ST175 clone, Spain.Emerging infectious diseases · 2012Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
The aim of this study was to identify class 1 integrons from extended-spectrum and metallo-beta-lactamase-negative, multidrug-resistant Pseudomonas aeruginosa clinical isolates from Hungary and to characterize the isolates by phenotypic and molecular methods. Fourteen selected P. aeruginosa isolates resistant to ceftazidime, gentamicin, and ciprofloxacin were subjected to serotyping, random amplification of polymorphic DNA (RAPD), integron content analysis, and a phenotypic test to detect high-level production of AmpC. Four representative isolates were further analyzed by multilocus sequence typing. Two P. aeruginosa multidrug-resistant clonal lineages were identified with a countrywide distribution. The first lineage is characterized by serotype O4, RAPD genotype A, sequence type ST175, and the presence of a class 1 integron harbouring aadB and aadA13 gene cassettes in its variable region. The second lineage is characterized by serotype O6, RAPD genotype B, sequence type ST395, and a class 1 integron carrying a single aadB cassette. The corresponding isolates were recovered from altogether 11 towns in Hungary. ST175 and ST395 are the presently calculated founders of two distinct P. aeruginosa clonal complexes that appear to have a wide geographical distribution also outside Hungary. The multidrug-resistant phenotype associated with these two clonal lineages might have contributed to an increase in their frequency and to their subsequent diversification. Both P. aeruginosa lineages displayed > or =8-fold synergy with boronic acid/ceftazidime combinations, suggesting an AmpC-mediated resistance to ceftazidime. Our observations underscore the role of class 1 integrons in the spread of aminoglycoside resistance by clonal dissemination among P. aeruginosa clinical isolates in Hungary.
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