Trial reportPsychopharmacology2009
Acute tryptophan depletion and self-injurious behavior in aggressive patients and healthy volunteers.
Trial report in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05563324 (Genetics of Self-injurious Behaviour), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetics of Self-injurious Behaviour
Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.Biological psychiatry · 2012Trial
- Chronic Obstructive Pulmonary Disease and Depression-The Vicious Mental Cycle.Healthcare (Basel, Switzerland) · 2025Review
- A nonhuman primate model of human non-suicidal self-injury: serotonin-transporter genotype-mediated typologies.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Elucidation of the Central Serotonin Metabolism Pathway in Rhesus Macaques (Comparative medicine · 2021Article
- Potential Mood Variation Following a Behavioral Analogue of Self-Injurious Behavior.Archives of suicide research : official journal of the International Academy for Suicide Research · 2020Article
- Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin.Neuroscience bulletin · 2019Article
- Hypoxia-related risk factors for death by suicide in a national clinical sample.Psychiatry research · 2019Article
- Effect of alcohol dose on deliberate self-harm in men and women.Journal of consulting and clinical psychology · 2017Article
- Nonsuicidal self-injury and interpersonal violence in U.S. veterans seeking help for posttraumatic stress disorder.Psychiatry research · 2017Article
- Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits.PloS one · 2015Article
- Article
- The role of the serotonergic system in suicidal behavior.Neuropsychiatric disease and treatment · 2013Review
- The effect of raising and lowering tryptophan levels on human mood and social behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Toxoplasma gondii seropositivity and suicide rates in women.The Journal of nervous and mental disease · 2011Article
- TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with HPA axis function and self-injurious behavior in rhesus monkeys.Genes, brain, and behavior · 2010Article
- Effects of acute tryptophan depletion on three different types of behavioral impulsivity.International journal of tryptophan research : IJTR · 2010Article
- Animal violence demystified.Frontiers in behavioral neuroscience · 2010Article
- Can dietary intervention help in management of problem behaviors in dementia?The journal of nutrition, health & aging · 2009Article
- Assessing Non-Suicidal Self-Injury in the Laboratory.Archives of suicide research : official journal of the International Academy for Suicide ResearchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleAn association between serotonin (5-HT) activity and self-injurious (i.e., self-aggressive) behavior across the spectrum of lethality (from self-mutilation through completed suicide) is a well-replicated finding. Studies to date, however, have relied on nonexperimental designs to examine this relationship, limiting the causal inferences that can be drawn about the role of 5-HT in self-aggressive behavior.
objectiveExamine the effect of experimentally altered 5-HT activity (via dietary tryptophan depletion) on self-aggressive behavior among adults with and without intermittent explosive disorder (IED). Individuals with a marked history of aggression, such as those with IED, are characterized by compromised 5-HT and heightened risk for self-aggression, making this a population of interest for examining the proposed relations. MATERIALS AND
methodsIED patients (n = 16) and healthy controls (n = 16) received a tryptophan depletion and a placebo drink on separate days at least 1 week apart. Self-aggressive behavior was assessed on both study days using a well-validated laboratory-based behavioral assessment with self-aggression defined as the intensity of shock self-administered.
resultsTryptophan depletion facilitated selection of more intense shocks, on average, in both groups. Patients with IED were also more self-aggressive overall than healthy volunteers. No IED by drink condition interactions were found.
conclusionExperimentally lowered 5-HT bioavailability enhances overall self-injurious behavior irrespective of aggression history.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.