ArticleFrontiers in cellular neuroscience2008
Upregulated H-current in hyperexcitable CA1 dendrites after febrile seizures.
Article in Frontiers in cellular neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 70 citations in OpenAlex.
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- Temporal Coordination of Hippocampal Neurons Reflects Cognitive Outcome Post-febrile Status Epilepticus.EBioMedicine · 2016Article
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- Homeostatic regulation of h-conductance controls intrinsic excitability and stabilizes the threshold for synaptic modification in CA1 neurons.The Journal of physiology · 2015Article
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4 authors at 1 institution in 1 country.
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Abstract
Somatic recordings from CA1 pyramidal cells indicated a persistent upregulation of the h-current (I(h)) after experimental febrile seizures. Here, we examined febrile seizure-induced long-term changes in I(h) and neuronal excitability in CA1 dendrites. Cell-attached recordings showed that dendritic I(h) was significantly upregulated, with a depolarized half-activation potential and increased maximal current. Although enhanced I(h) is typically thought to be associated with decreased dendritic excitability, whole-cell dendritic recordings revealed a robust increase in action potential firing after febrile seizures. We turned to computational simulations to understand how the experimentally observed changes in I(h) influence dendritic excitability. Unexpectedly, the simulations, performed in three previously published CA1 pyramidal cell models, showed that the experimentally observed increases in I(h) resulted in a general enhancement of dendritic excitability, primarily due to the increased I(h)-induced depolarization of the resting membrane potential overcoming the excitability-depressing effects of decreased dendritic input resistance. Taken together, these experimental and modeling results reveal that, contrary to the exclusively anti-convulsive role often attributed to increased I(h) in epilepsy, the enhanced I(h) can co-exist with, and possibly even contribute to, persistent dendritic hyperexcitability following febrile seizures in the developing hippocampus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.