ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2008
Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
- Effects of Lipid Shape and Interactions on the Conformation, Dynamics, and Curvature of Ultrasound-Responsive Liposomes.Pharmaceutics · 2022Article
- Echogenic Exosomes as ultrasound contrast agents.Nanoscale advances · 2020Article
- Ultrasound-Responsive Materials for Drug/Gene Delivery.Frontiers in pharmacology · 2019Review
- Multifunctional polymersomes for cytosolic delivery of gemcitabine and doxorubicin to cancer cells.Biomaterials · 2014Article
- Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery.Computational mechanics · 2014Article
- Nitric oxide-loaded echogenic liposomes for treatment of vasospasm following subarachnoid hemorrhage.International journal of nanomedicine · 2014Article
- The impact of bubbles on measurement of drug release from echogenic liposomes.Ultrasonics sonochemistry · 2013Article
- Ultrasound-mediated drug delivery for cardiovascular disease.Expert opinion on drug delivery · 2013Review
- Polymer-coated echogenic lipid nanoparticles with dual release triggers.Biomacromolecules · 2013Article
- Ultrasound enhanced matrix metalloproteinase-9 triggered release of contents from echogenic liposomes.Molecular pharmaceutics · 2012Article
- In vitro measurement of attenuation and nonlinear scattering from echogenic liposomes.Ultrasonics · 2012Article
- Acoustic characterization of echogenic liposomes: frequency-dependent attenuation and backscatter.The Journal of the Acoustical Society of America · 2011Article
- Phase-shift, stimuli-responsive drug carriers for targeted delivery.Therapeutic delivery · 2011Review
- Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions.Journal of controlled release : official journal of the Controlled Release Society · 2011Article
- Delivery of chlorambucil using an acoustically-triggered perfluoropentane emulsion.Ultrasound in medicine & biology · 2010Article
- Ultrasound-enhanced delivery of targeted echogenic liposomes in a novel ex vivo mouse aorta model.Journal of controlled release : official journal of the Controlled Release Society · 2010Article
- Ultrasound-mediated delivery of echogenic immunoliposomes to porcine vascular smooth muscle cells in vivo.Journal of liposome research · 2010Article
- Kinetics and Thermodynamics of Acoustic Release of Doxorubicin from Non-stabilized polymeric Micelles.Colloids and surfaces. A, Physicochemical and engineering aspects · 2010Article
- Ultrasonic nanotherapy of pancreatic cancer: lessons from ultrasound imaging.Molecular pharmaceutics · 2010Article
- Ultrasound-triggered release of recombinant tissue-type plasminogen activator from echogenic liposomes.Ultrasound in medicine & biology · 2010Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo achieve ultrasound-controlled drug delivery using echogenic liposomes (ELIPs), we assessed ultrasound-triggered release of hydrophilic and lipophilic agents in vitro using color Doppler ultrasound delivered with a clinical 6-MHz compact linear array transducer.
methodsCalcein, a hydrophilic agent, and papaverine, a lipophilic agent, were each separately loaded into ELIPs. Calcein-loaded ELIP (C-ELIP) and papaverine-loaded ELIP (P-ELIP) solutions were circulated in a flow model and treated with 6-MHz color Doppler ultrasound or Triton X-100. Treatment with Triton X-100 was used to release the encapsulated calcein or papaverine content completely. The free calcein concentration in the solution was measured directly by spectrofluorimetry. The free papaverine in the solution was separated from liposome-bound papaverine by spin column filtration, and the resulting papaverine concentration was measured directly by absorbance spectrophotometry. Dynamic changes in echogenicity were assessed with low-output B-mode ultrasound (mechanical index, 0.04) as mean digital intensity.
resultsColor Doppler ultrasound caused calcein release from C-ELIPs compared with flow alone (P < .05) but did not induce papaverine release from P-ELIPs compared with flow alone (P > .05). Triton X-100 completely released liposome-associated calcein and papaverine. Initial echogenicity was higher for C-ELIPs than P-ELIPs. Color Doppler ultrasound and Triton X-100 treatments reduced echogenicity for both C-ELIPs and P-ELIPs (P < .05).
conclusionsThe differential efficiency of ultrasound-mediated pharmaceutical release from ELIPs for water- and lipid-soluble compounds suggests that water-soluble drugs are better candidates for the design and development of ELIP-based ultrasound-controlled drug delivery systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.