ArticleMolecular biology of the cell2009
Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review).Oncology reports · 2023Article
- Article
- Mechanism and Disease Association With a Ubiquitin Conjugating E2 Enzyme: UBE2L3.Frontiers in immunology · 2022Review
- MYO10 drives genomic instability and inflammation in cancer.Science advances · 2021Article
- UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin.Cells · 2021Article
- A Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes.International journal of molecular sciences · 2021Article
- Stabilization of p27FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols.Journal of visualized experiments : JoVE · 2017Article
- Regulatory cross-talk determines the cellular levels of 53BP1 protein, a critical factor in DNA repair.The Journal of biological chemistry · 2017Article
- The efficacy and safety of Collagen-I and hypoxic conditions in urine-derived stem cellTissue engineering and regenerative medicine · 2016Article
- E2 enzymes: more than just middle men.Cell research · 2016Review
- UbcH7 regulates 53BP1 stability and DSB repair.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases.Journal of medicinal chemistry · 2014Article
- Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells.DNA repair · 2014Article
- Article
- Ube2l3 gene expression is modulated by activation of the aryl hydrocarbon receptor: implications for p53 ubiquitination.Biochemical pharmacology · 2010Article
- Maintaining genome stability at the replication fork.Nature reviews. Molecular cell biology · 2010Review
- Ubiquitin control of S phase: a new role for the ubiquitin conjugating enzyme, UbcH7.Cell division · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Timely degradation of regulatory proteins by the ubiquitin proteolytic pathway (UPP) is an established paradigm of cell cycle regulation during the G2/M and G1/S transitions. Less is known about roles for the UPP during S phase. Here we present evidence that dynamic cell cycle-dependent changes in levels of UbcH7 regulate entrance into and progression through S phase. In diverse cell lines, UbcH7 protein levels are dramatically reduced in S phase but are fully restored by G2. Knockdown of UbcH7 increases the proportion of cells in S phase and doubles the time to traverse S phase, whereas UbcH7 overexpression reduces the proportion of cells in S phase. These data suggest a role for UbcH7 targets in the completion of S phase and entry into G2. Notably, UbcH7 knockdown was coincident with elevated levels of the checkpoint kinase Chk1 but not Chk2. These results argue that UbcH7 promotes S phase progression to G2 by modulating the intra-S phase checkpoint mediated by Chk1. Furthermore, UbcH7 levels appear to be regulated by a UPP. Together the data identify novel roles for the UPP, specifically UbcH7 in the regulation of S phase transit time as well as in cell proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.