ArticleJournal of cell science2008
Fusion-pore expansion during syncytium formation is restricted by an actin network.
Article in Journal of cell science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Virus-Induced Cell Fusion and Syncytia Formation.Results and problems in cell differentiation · 2024Article
- Osteoclasts at Bone Remodeling: Order from Order.Results and problems in cell differentiation · 2024Review
- Productive HIV-1 infection of tissue macrophages by fusion with infected CD4+ T cells.The Journal of cell biology · 2023Article
- Adopted neoplastic cells and the consequences of their existence.Oncotarget · 2023Article
- Envelope-Fusion-Syncytium Formation inViruses · 2022Article
- YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion.Nature communications · 2021Article
- Article
- Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion.PLoS pathogens · 2020Article
- Article
- Stochastic modeling of nanoparticle internalization and expulsion through receptor-mediated transcytosis.Nanoscale · 2019Article
- SNARE-mediated membrane fusion arrests at pore expansion to regulate the volume of an organelle.The EMBO journal · 2018Article
- Geometry of the Contact Zone between Fused Membrane-Coated Beads Mimicking Cell-Cell Fusion.Biophysical journal · 2016Article
- Surface apposition and multiple cell contacts promote myoblast fusion in Drosophila flight muscles.The Journal of cell biology · 2015Article
- Article
- Membrane tension and membrane fusion.Current opinion in structural biology · 2015Review
- Distinct requirements for HIV-cell fusion and HIV-mediated cell-cell fusion.The Journal of biological chemistry · 2015Article
- Spatiotemporal detection and analysis of exocytosis reveal fusion "hotspots" organized by the cytoskeleton in endocrine cells.Biophysical journal · 2015Article
- Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin.The Biochemical journal · 2014Article
- Ezrin is a component of the HIV-1 virological presynapse and contributes to the inhibition of cell-cell fusion.Journal of virology · 2014Article
- Sperm-egg fusion: a molecular enigma of mammalian reproduction.International journal of molecular sciences · 2014Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Cell-cell fusion in animal development and in pathophysiology involves expansion of nascent fusion pores formed by protein fusogens to yield an open lumen of cell-size diameter. Here we explored the enlargement of micron-scale pores in syncytium formation, which was initiated by a well-characterized fusogen baculovirus gp64. Radial expansion of a single or, more often, of multiple fusion pores proceeds without loss of membrane material in the tight contact zone. Pore growth requires cell metabolism and is accompanied by a local disassembly of the actin cortex under the pores. Effects of actin-modifying agents indicate that the actin cortex slows down pore expansion. We propose that the growth of the strongly bent fusion-pore rim is restricted by a dynamic resistance of the actin network and driven by membrane-bending proteins that are involved in the generation of highly curved intracellular membrane compartments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.