ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Reduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms.Cancers · 2025Review
- Sprouting of afferent and efferent inputs to pelvic organs after spinal cord injury.Journal of neuropathology and experimental neurology · 2023Article
- Upregulated 5-HTJournal of neurotrauma · 2023Article
- Molecular Mechanisms of Neurogenic Lower Urinary Tract Dysfunction after Spinal Cord Injury.International journal of molecular sciences · 2023Review
- Effects of a neurokinin-1 receptor antagonist in the acute phase after thoracic spinal cord injury in a rat model.Frontiers in molecular neuroscience · 2023Article
- Lipopolysaccharides induce a RAGE-mediated sensitization of sensory neurons and fluid hypersecretion in the upper airways.Scientific reports · 2021Article
- Choice of cystometric technique impacts detrusor contractile dynamics in wistar rats.Physiological reports · 2021Article
- Nerve sprouting and neurogenic inflammation characterize the neurogenic detrusor overactive bladder of patients no longer responsive to drug therapies.Journal of cellular and molecular medicine · 2019Article
- Axonal Injury Induces ATF3 in Specific Populations of Sacral Preganglionic Neurons in Male Rats.Frontiers in neuroscience · 2018Article
- Article
- Spinal Transection Alters External Urethral Sphincter Activity during Spontaneous Voiding in Freely Moving Rats.Journal of neurotrauma · 2017Article
- Netupitant, a Potent and Highly Selective NK1 Receptor Antagonist, Alleviates Acetic Acid-Induced Bladder Overactivity in Anesthetized Guinea-Pigs.Frontiers in pharmacology · 2016Article
- Research Findings on Overactive Bladder.Current urology · 2015Review
- Neural control of the lower urinary tract.Comprehensive Physiology · 2015Review
- Neural mechanisms underlying lower urinary tract dysfunction.Korean journal of urology · 2014Review
- Enhanced susceptibility to urinary tract infection in the spinal cord-injured host with neurogenic bladder.Infection and immunity · 2013Article
- Plasticity in reflex pathways to the lower urinary tract following spinal cord injury.Experimental neurology · 2012Review
- Plasticity of non-adrenergic non-cholinergic bladder contractions in rats after chronic spinal cord injury.Brain research bulletin · 2011Article
- Current Knowledge and Novel Frontiers in Lower Urinary Tract Dysfunction after Spinal Cord Injury: Basic Research Perspectives.Urological scienceArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The primary afferent neurotransmitter triggering the spinal micturition reflex after complete spinal cord injury (SCI) in the rat is unknown. Substance P detected immunohistochemically in the sacral parasympathetic nucleus was significantly higher in 12 SCI rats than in 12 spinally intact rats (P = 0.008), suggesting substance P as a plausible candidate for the primary afferent neurotransmitter. The effects of the tachykinin NK1 receptor antagonist L-733060 on the spinal micturition reflex were then determined by performing conscious cystometry in an additional 14 intact rats and 14 SCI rats with L-733060 (0.1-100 microg) administered intrathecally at L6-S1. L-733060 was without effect in intact rats, but blocked the spinal micturition reflex in 10 of 14 SCI rats and increased the intermicturition interval in 2 of 4 others at doses ranging from 10 to 100 microg. Both phasic and nonphasic voiding contractions, differentiated according to the presence of phasic external urethral sphincter (EUS) activity, were present in most SCI rats. Both types of contractions were blocked by high doses of L-733060. Interestingly, there was a relative decline in phasic voiding contractions at high doses as well as a decline in contraction amplitude in nonphasic voiding contractions. In other respects, cystometric variables were largely unaffected in either spinally intact or SCI rats. L-733060 did not affect tonic EUS activity at any dose except when the spinal micturition reflex was blocked and tonic activity was consequently lost. These experiments show that tachykinin action at spinal NK1 receptors plays a major role in the spinal micturition reflex in SCI rats.
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Registered trials
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