ArticlePlant physiology2008
Arabidopsis casein kinase 1-like 6 contains a microtubule-binding domain and affects the organization of cortical microtubules,.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 89 citations in OpenAlex.
- Article
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- The unconventional TPX2 family protein TPXL3 regulates α Aurora kinase function in spindle morphogenesis in Arabidopsis.The Plant cell · 2025Article
- Visualizing the dynamics of plant energy organelles.Biochemical Society transactions · 2023Article
- The rubber tree kinome: Genome-wide characterization and insights into coexpression patterns associated with abiotic stress responses.Frontiers in plant science · 2023Article
- Integration of transcriptomic and proteomic analyses reveals several levels of metabolic regulation in the excess starch and early senescent leaf mutant lses1 in rice.BMC plant biology · 2022Article
- Plant casein kinases phosphorylate and destabilize a cyclin-dependent kinase inhibitor to promote cell division.Plant physiology · 2021Article
- Split-HaloTag imaging assay for sophisticated microscopy of protein-protein interactionsPlant communications · 2021Article
- Phosphorylation Site Motifs in Plant Protein Kinases and Their Substrates.Methods in molecular biology (Clifton, N.J.) · 2021Review
- FRA1 Kinesin Modulates the Lateral Stability of Cortical Microtubules through Cellulose Synthase-Microtubule Uncoupling Proteins.The Plant cell · 2020Article
- Article
- Heat-induced inhibition of phosphorylation of the stress-protective transcription factor DREB2A promotes thermotolerance ofThe Journal of biological chemistry · 2019Article
- Tethering of Multi-Vesicular Bodies and the Tonoplast to the Plasma Membrane in Plants.Frontiers in plant science · 2019Article
- Brassinosteroids regulate pavement cell growth by mediating BIN2-induced microtubule stabilization.Journal of experimental botany · 2018Article
- Article
- Genome-wide classification, evolutionary analysis and gene expression patterns of the kinome in Gossypium.PloS one · 2018Article
- Genome-wide identification, classification, evolutionary analysis and gene expression patterns of the protein kinase gene family in wheat and Aegilops tauschii.Plant molecular biology · 2017Article
- Directional cell expansion requires NIMA-related kinase 6 (NEK6)-mediated cortical microtubule destabilization.Scientific reports · 2017Article
- The Molybdenum Cofactor Biosynthesis Network:Frontiers in plant science · 2017Review
- CASEIN KINASE1-LIKE PROTEIN2 Regulates Actin Filament Stability and Stomatal Closure via Phosphorylation of Actin Depolymerizing Factor.The Plant cell · 2016Article
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6 authors at 2 institutions in 1 country.
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Abstract
Members of the casein kinase 1 (CK1) family are evolutionarily conserved eukaryotic protein kinases that are involved in various cellular, physiological, and developmental processes in yeast and metazoans, but the biological roles of CK1 members in plants are not well understood. Here, we report that an Arabidopsis (Arabidopsis thaliana) CK1 member named casein kinase 1-like 6 (CKL6) associates with cortical microtubules in vivo and phosphorylates tubulins in vitro. The unique C-terminal domain of CKL6 was shown to contain the signal that allows localization of CKL6 to the cortical microtubules. This domain on its own was sufficient to associate with microtubules in vivo and to bind tubulins in vitro. CKL6 was able to phosphorylate soluble tubulins as well as microtubule polymers, and its endogenous activity was found to associate with a tubulin-enriched subcellular fraction. Two major in vitro phosphorylation sites were mapped to serine-413 and serine-420 of tubulin beta. Ectopic expression of wild-type CKL6 or a kinase-inactive mutant form induced alterations in cortical microtubule organization and anisotropic cell expansion. Collectively, these results demonstrate that CKL6 is a protein kinase containing a novel tubulin-binding domain and plays a role in anisotropic cell growth and shape formation in Arabidopsis through the regulation of microtubule organization, possibly through the phosphorylation of tubulins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.