ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Turning astrocytes from the rostral migratory stream into neurons: a role for the olfactory sensory organ.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 122 citations in OpenAlex.
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Olfactory Dysfunction in a Novel Model of Prodromal Parkinson's Disease in Adult Zebrafish.International journal of molecular sciences · 2025Article
- Timing Matters: Lessons From Perinatal Neurogenesis in the Olfactory Bulb.The Journal of comparative neurology · 2025Article
- Glial cells in the mammalian olfactory bulb.Frontiers in cellular neuroscience · 2024Review
- Development of the mammalian main olfactory bulb.Development (Cambridge, England) · 2022Review
- Morphological Diversity of Calretinin Interneurons Generated From Adult Mouse Olfactory Bulb Core Neural Stem Cells.Frontiers in cell and developmental biology · 2022Article
- Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia.International journal of molecular sciences · 2021Review
- Parallel astrocyte calcium signaling modulates olfactory bulb responses.Journal of neuroscience research · 2020Article
- Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis.Cell stem cell · 2020Article
- Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Neural plasticity · 2020Article
- Neurogenesis From Embryo to Adult - Lessons From Flies and Mice.Frontiers in cell and developmental biology · 2020Review
- HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice.Frontiers in neuroanatomy · 2020Article
- Neuronal precursor cells with dopaminergic commitment in the rostral migratory stream of the mouse.Scientific reports · 2019Article
- Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Adult Born Periglomerular Cells of Odorant Receptor Specific Glomeruli.Frontiers in neuroanatomy · 2018Article
- Label retention and stem cell marker expression in the developing and adult prostate identifies basal and luminal epithelial stem cell subpopulations.Stem cell research & therapy · 2017Article
- Clonal Mapping of Astrocytes in the Olfactory Bulb and Rostral Migratory Stream.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Human adult neurogenesis across the ages: An immunohistochemical study.Neuropathology and applied neurobiology · 2016Article
- Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream.Scientific reports · 2016Article
- Transplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regeneration.Acta biomaterialia · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Neurogenesis persists within a few restricted areas of the adult mammalian brain, giving rise to neurons that functionally integrate into preexisting circuits. One of these areas, the subventricular zone (SVZ), was believed, until recently, to be the unique source providing the adult olfactory bulb (OB) with newborn neurons. Because of the fact that neuroblasts derived in the SVZ migrate through the rostral migratory stream (RMS) en route to the OB, the existence of candidate neural stem cells within the RMS was long overlooked. Here, we confirm and considerably extend recent evidence for the existence of adult neural stem cells within the RMS, and go on to investigate their proliferative regulation. Specifically targeting RMS-astrocytes with lentiviral vectors encoding GFP, we demonstrate that glial cells in the RMS differentiate into both OB granule and periglomerular interneurons. In addition, ultrastructural analysis unambiguously reveals the astrocytic nature of stem cells in the adult RMS, and patch-clamp recordings demonstrate the functional integration of RMS-derived interneurons into OB circuitry. Proliferative regulation was investigated via two contrasting manipulations: exposure to an odor-enriched environment that enhances candidate stem cell proliferation in both the RMS and SVZ, and chemical lesion of the main olfactory epithelium that increases cell proliferation in the RMS only. New neurons in the adult OB can therefore arise from different neurogenic areas that can be separately regulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.