ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Glutamate transporter-mediated glutamate secretion in the mammalian pineal gland.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A Glial-Neuronal Circuit in the Median Eminence Regulates Thyrotropin-Releasing Hormone-Release via the Endocannabinoid System.iScience · 2020Article
- GABAergic signaling in the rat pineal gland.Journal of pineal research · 2016Article
- High membrane permeability for melatonin.The Journal of general physiology · 2016Article
- Noradrenaline upregulates T-type calcium channels in rat pinealocytes.The Journal of physiology · 2015Article
- Modulation of nicotinic receptor channels by adrenergic stimulation in rat pinealocytes.American journal of physiology. Cell physiology · 2014Article
- Developmental and diurnal expression of the synaptosomal-associated protein 25 (Snap25) in the rat pineal gland.Neurochemical research · 2013Article
- Leptin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland.BioMed research international · 2013Article
- Modulation of pineal melatonin synthesis by glutamate involves paracrine interactions between pinealocytes and astrocytes through NF-κB activation.BioMed research international · 2013Article
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
Glutamate transporters are expressed throughout the CNS where their major role is to clear released glutamate from presynaptic terminals. Here, we report a novel function of the transporter in rat pinealocytes. This electrogenic transporter conducted inward current in response to L-glutamate and L- or D-aspartate and depolarized the membrane in patch-clamp experiments. Ca2+ imaging demonstrated that the transporter-mediated depolarization induced a significant Ca2+ influx through voltage-gated Ca2+ channels. The Ca2+ rise finally evoked glutamate exocytosis as detected by carbon-fiber amperometry and by HPLC. In pineal slices with densely packed pinealocytes, glutamate released from the cells effectively activated glutamate transporters in neighboring cells. The Ca2+ signal generated by KCl depolarization or acetylcholine propagated through several cell layers by virtue of the regenerative "glutamate-induced glutamate release." Therefore, we suggest that glutamate transporters mediate synchronized elevation of L-glutamate and thereby efficiently downregulate melatonin secretion via previously identified inhibitory metabotropic glutamate receptors in the pineal gland.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.