ReviewMolecular pharmacology2009
Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors.
Review in Molecular pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Two entry tunnels in mouse TAAR9 suggest the possibility of multi-entry tunnels in olfactory receptors.Scientific reports · 2022Article
- Stereospecific modulation of dimeric rhodopsin.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Membrane cholesterol access into a G-protein-coupled receptor.Nature communications · 2017Article
- Novel Structural Approaches to Study GPCR Regulation.International journal of molecular sciences · 2016Review
- Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor.Journal of molecular endocrinology · 2015Article
- Structure and function of serotonin G protein-coupled receptors.Pharmacology & therapeutics · 2015Review
- Conformational selection and equilibrium governs the ability of retinals to bind opsin.The Journal of biological chemistry · 2015Article
- Transmembrane domains of attraction on the TSH receptor.Endocrinology · 2015Article
- From atomic structures to neuronal functions of g protein-coupled receptors.Annual review of neuroscience · 2013Review
- Structural and functional relationships between photoreceptor tetraspanins and other superfamily members.Cellular and molecular life sciences : CMLS · 2012Review
- Bihelix: Towards de novo structure prediction of an ensemble of G-protein coupled receptor conformations.Proteins · 2012Article
- Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Microscopic binding of M5 muscarinic acetylcholine receptor with antagonists by homology modeling, molecular docking, and molecular dynamics simulation.The journal of physical chemistry. B · 2012Article
- Article
- G protein-coupled receptors--recent advances.Acta biochimica Polonica · 2012Review
- Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool.PloS one · 2012Article
- Characterizing and predicting the functional and conformational diversity of seven-transmembrane proteins.Methods (San Diego, Calif.) · 2011Article
- The significance of G protein-coupled receptor crystallography for drug discovery.Pharmacological reviews · 2011Review
- Homology model and docking studies on porcine β₂ adrenoceptor: description of two binding sites.Journal of molecular modeling · 2011Article
- Successful prediction of the intra- and extracellular loops of four G-protein-coupled receptors.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Biological membranes are densely packed with membrane proteins that occupy approximately half of their volume. In almost all cases, membrane proteins in the native state lack the higher-order symmetry required for their direct study by diffraction methods. Despite many technical difficulties, numerous crystal structures of detergent solubilized membrane proteins have been determined that illustrate their internal organization. Among such proteins, class A G protein-coupled receptors have become amenable to crystallization and high resolution X-ray diffraction analyses. The derived structures of native and engineered receptors not only provide insights into their molecular arrangements but also furnish a framework for designing and testing potential models of transformation from inactive to active receptor signaling states and for initiating rational drug design.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.