ArticleRNA (New York, N.Y.)2008
Intragenic rearrangements of a mycoreovirus induced by the multifunctional protein p29 encoded by the prototypic hypovirus CHV1-EP713.
Article in RNA (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 78 citations in OpenAlex.
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- Development of an attenuated potato virus Y mutant carrying multiple mutations in helper-component protease for cross-protection.Virus research · 2024Article
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- A maize triacylglycerol lipase inhibits sugarcane mosaic virus infection.Plant physiology · 2022Article
- A second capsidless hadakavirus strain with 10 positive-sense single-stranded RNA genomic segments from Fusarium nygamai.Archives of virology · 2021Article
- Infection of Two Heterologous Mycoviruses Reduces the Virulence ofFrontiers in microbiology · 2021Article
- Development and Evaluation of Stable Sugarcane Mosaic Virus Mild Mutants for Cross-Protection Against Infection by Severe Strain.Frontiers in plant science · 2021Article
- Unique Terminal Regions and Specific Deletions of the Segmented Double-Stranded RNA Genome of Alternaria Alternata Virus 1, in the Proposed Family Alternaviridae.Frontiers in microbiology · 2021Article
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- Facilitative and synergistic interactions between fungal and plant viruses.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Molecular Characterization of a Novel Polymycovirus FromFrontiers in microbiology · 2020Article
- A Spontaneous Complementary Mutation Restores the RNA Silencing Suppression Activity of HC-Pro and the Virulence of Sugarcane Mosaic Virus.Frontiers in plant science · 2020Article
- Symptomatic plant viroid infections in phytopathogenic fungi.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Identification of a Novel Hypovirulence-Inducing Hypovirus FromFrontiers in microbiology · 2019Article
- Determinants of Coinfection in the Mycoviruses.Frontiers in cellular and infection microbiology · 2019Article
- Molecular Characterization of a Chrysovirus Isolated From the Citrus PathogenFrontiers in cellular and infection microbiology · 2019Article
- A phloem-limited fijivirus induces the formation of neoplastic phloem tissues that house virus multiplication in the host plant.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycoreovirus 1 (MyRV1), a member of the Reoviridae family possessing a genome consisting of 11 dsRNA segments (S1-S11), and the prototype hypovirus (CHV1-EP713) of the Hypoviridae family, which is closely related to the monopartite picorna-like superfamily with a ssRNA genome, infect the chestnut blight fungus and cause virulence attenuation and distinct phenotypic alterations in the host. Here, we present evidence for reproducible induction of intragenic rearrangements of MyRV1 S6 and S10, mediated by the multifunctional protein p29 encoded by CHV1. S6 and S10 underwent an almost full-length ORF duplication (S6L) and an internal deletion of three-fourths of the ORF (S10ss). No significant influence on symptom induction in the fungal host was associated with the S6L rearrangement. In contrast, S10-encoded VP10, while nonessential for MyRV1 replication, was shown to contribute to virulence reduction and reduced growth of aerial mycelia. Furthermore, p29 was found to copurify with MyRV1 genomic RNA and bind to VP9 in vitro and in vivo, suggesting direct interactions of p29 with the MyRV1 replication machinery. This study provides the first example of a viral factor involved in RNA genome rearrangements of a different virus and shows its usefulness as a probe into the mechanism of replication and symptom expression of a heterologous virus.
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