ArticleJournal of virology2009
Association of simian virus 40 vp1 with 70-kilodalton heat shock proteins and viral tumor antigens.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- THRESHOLD: a comprehensive transcriptomic analysis tool for evaluating gene saturation and impact in disease progression.NAR cancer · 2025Article
- Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera).BMC biology · 2025Article
- ATeam technology for detecting early signs of viral cytopathic effect.The Journal of veterinary medical science · 2020Article
- Cucumber Necrosis Virus Recruits Cellular Heat Shock Protein 70 Homologs at Several Stages of Infection.Journal of virology · 2015Article
- Inhibition of large T antigen ATPase activity as a potential strategy to develop anti-polyomavirus JC drugs.Antiviral research · 2014Article
- A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.PLoS pathogens · 2014Article
- Article
- Formation of covalently modified folding intermediates of simian virus 40 Vp1 in large T antigen-expressing cells.Journal of virology · 2013Article
- Recruitment of the host plant heat shock protein 70 by Tomato yellow leaf curl virus coat protein is required for virus infection.PloS one · 2013Article
- Cysteine residues in the major capsid protein, Vp1, of the JC virus are important for protein stability and oligomer formation.PloS one · 2013Article
- Differential roles of Hsp70 and Hsp90 in the assembly of the replicase complex of a positive-strand RNA plant virus.Journal of virology · 2012Article
- Principles of polyoma- and papillomavirus uncoating.Medical microbiology and immunology · 2012Review
- Disassociation of the SV40 genome from capsid proteins prior to nuclear entry.Virology journal · 2012Article
- Visualization and measurement of ATP levels in living cells replicating hepatitis C virus genome RNA.PLoS pathogens · 2012Article
- A large and intact viral particle penetrates the endoplasmic reticulum membrane to reach the cytosol.PLoS pathogens · 2011Article
- Article
- HSP70 and its cochaperone CPIP promote potyvirus infection in Nicotiana benthamiana by regulating viral coat protein functions.The Plant cell · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Proper folding of newly synthesized viral proteins in the cytoplasm is a prerequisite for the formation of infectious virions. The major capsid protein Vp1 of simian virus 40 forms a series of disulfide-linked intermediates during folding and capsid formation. In addition, we report here that Vp1 is associated with cellular chaperones (HSP70) and a cochaperone (Hsp40) which can be coimmunoprecipitated with Vp1. Studies in vitro demonstrated the ATP-dependent interaction of Vp1 and cellular chaperones. Interestingly, viral cochaperones LT and ST were essential for stable interaction of HSP70 with the core Vp1 pentamer Vp1 (22-303). LT and ST also coimmunoprecipitated with Vp1 in vivo. In addition to these identified (co)chaperones, stable, covalently modified forms of Vp1 were identified for a folding-defective double mutant, C49A-C87A, and may represent a "trapped" assembly intermediate. By a truncation of the carboxyl arm of Vp1 to prevent the Vp1 folding from proceeding beyond pentamers, we detected several apparently modified Vp1 species, some of which were absent in cells transfected with the folding-defective mutant DNA. These results suggest that transient covalent interactions with known or unknown cellular and viral proteins are important in the assembly process.
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Registered trials
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