ArticleHaematologica2008
Donor/recipient mixed chimerism does not predict graft failure in children with beta-thalassemia given an allogeneic cord blood transplant from an HLA-identical sibling.
Article in Haematologica, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Hematopoietic stem cell transplantation in thalassemia major and sickle cell disease: indications and management recommendations from an international expert panel.Haematologica · 2014Guideline
- [Guideline for allogeneic hematopoietic stem cell transplantation in the treatment of transfusion-dependent thalassemia in China (2026)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Across the Myeloablative Spectrum: Hematopoietic Cell Transplant Conditioning Regimens for Pediatric Patients with Sickle Cell Disease.Journal of clinical medicine · 2022Review
- Article
- Chimerism in the Realm of Hematopoietic Stem Cell Transplantation for Non-malignant Disorders-A Perspective.Frontiers in immunology · 2020Article
- The case for HLA-identical sibling hematopoietic stem cell transplantation in children with symptomatic sickle cell anemia.Blood advances · 2017Article
- Is the Benefit-Risk Ratio for Patients with Transfusion-Dependent Thalassemia Treated by Unrelated Cord Blood Transplantation Favorable?International journal of molecular sciences · 2017Review
- Alternative Donor/Unrelated Donor Transplants for the β-Thalassemia and Sickle Cell Disease.Advances in experimental medicine and biology · 2017Article
- Current and future alternative therapies for beta-thalassemia major.Biomedical journal · 2016Review
- Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia.Haematologica · 2014Article
- Hematopoietic stem-cell transplantation for sickle cell disease: current evidence and opinions.Therapeutic advances in hematology · 2013Article
- Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation: priorities of the Westhafen Intercontinental Group.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2013Article
- Umbilical cord blood: an evolving stem cell source for sickle cell disease transplants.Stem cells translational medicine · 2013Review
- Umbilical cord blood transplantation for children with thalassemia and sickle cell disease.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2011Article
- Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat β-thalassemia.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- What is the minimum level of donor chimerism necessary to sustain transfusion independence in thalassaemia?Bone marrow transplantation · 2011Article
- Split chimerism between nucleated and red blood cells after bone marrow transplantation for haemoglobinopathies.Chimerism · 2011Article
- In mixed hematopoietic chimerism, the donor red cells win.Haematologica · 2011Article
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Authors and funding
14 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDonor/recipient mixed chimerism has been reported to be associated with an increased risk of graft failure in patients with beta-thalassemia given a bone marrow transplant. We investigated the relationship between the degree of mixed chimerism over time and clinical outcome of children undergoing cord blood transplantation for beta-thalassemia. DESIGN AND
methodsTwenty-seven consecutive children given a cord blood transplant from a related donor were analyzed by short tandem repeat polymerase chain reaction and their chimerism results were compared with those of 79 consecutive patients who received a bone marrow transplant from either a relative (RD-BMT, n=42) or an unrelated donor (UD-BMT, n=37). Cord blood and bone marrow recipients received comparable preparative regimens.
resultsAll cord blood recipients engrafted and displayed mixed chimerism early after transplantation; 13/27 converted to full donor chimerism over time, while 14 maintained stable mixed chimerism; all patients are alive and transfusion-independent. Twenty-four of the 79 bone marrow-recipients (12 UD- and 12 RD-BMT) exhibited full donor chimerism at all time points examined, 4/79 (2 UD- and 2 RD-BMT) did not engraft and 51/79 (23 UD- and 28 RD-BMT) displayed mixed chimerism at the time of hematologic reconstitution. Forty of 51 bone marrow recipients with mixed chimerism converted to full donor chimerism (17 UD- and 23 RD-BMT), 3/51 maintained stable mixed chimerism (1 UD- and 2 RD-BMT), while 8/51 (5 UD- and 3 RD-BMT) progressively lost the graft, and became transfusion-dependent again.
conclusionsMixed chimerism is a frequent event and does not predict the occurrence of graft failure in children with beta-thalassemia given a cord blood transplant from a relative.
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