ArticleThe Journal of biological chemistry2008
Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
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- A Single-Center, Randomized, Double-Blind, and Placebo-Controlled Comparative Human Study to Verify the Functionality and Safety of the Lespedeza cuneata G. Don Extract for the Improvement of Aging Male Syndrome.Urology research & practice · 2023Article
- The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism.Genes & development · 2020Review
- Frog (Pelophylax bergeri, Günther 1986) endocrine disruption assessment: characterization and role of skin poly(ADP-ribose) polymerases.Environmental science and pollution research international · 2018Article
- Article
- Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.Cell proliferation · 2017Article
- An update on PARP inhibitors--moving to the adjuvant setting.Nature reviews. Clinical oncology · 2015Review
- Aging impairs VEGF-mediated, androgen-dependent regulation of angiogenesis.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Heterogeneous nuclear ribonucleoprotein (HnRNP) K genome-wide binding survey reveals its role in regulating 3'-end RNA processing and transcription termination at the early growth response 1 (EGR1) gene through XRN2 exonuclease.The Journal of biological chemistry · 2013Article
- SULT2B1b sulfotransferase: induction by vitamin D receptor and reduced expression in prostate cancer.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Article
- Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis.Cell death and differentiation · 2012Article
- The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells.The Prostate · 2012Article
- Metabolic and cardiovascular genes in polycystic ovary syndrome: a candidate-wide association study (CWAS).Steroids · 2012Article
- Regulation of chromatin structure by poly(ADP-ribosyl)ation.Frontiers in genetics · 2012Article
- The role of nuclear matrix proteins binding to matrix attachment regions (Mars) in prostate cancer cell differentiation.PloS one · 2012Article
- Krüppel-like factor 6 regulates transforming growth factor-β gene expression during human respiratory syncytial virus infection.Virology journal · 2011Article
- Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase.Molecular endocrinology (Baltimore, Md.) · 2011Article
- T2DM: Why Epigenetics?Journal of nutrition and metabolism · 2011Article
- Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells.Oncogene · 2010Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Poly(ADP-ribosyl)ation of transcription factors and coregulators, mediated by the poly(ADP-ribose) polymerase PARP-1, has been emerging as an important epigenetic mechanism that controls transcriptional dynamics in response to diverse intra- and extracellular signals. PARP-1 activity is also implicated in the regulation of mammalian lifespan. Herein we show that transcriptional down-regulation of androgen receptor (AR) in the aging rat liver and in oxidatively stressed hepatoma cells involves exchange of a PARP-1-associated, p/CAF-containing coactivator assembly for a p53-interacting, Groucho/TLE1-, and mSin3A-included corepressor complex at an age- and oxidant-responsive DNA element (age-dependent factor (ADF) element) in the AR promoter. The coregulator switch is mediated by B-Myb and c-Myb, which bind to the ADF element and physically associate with PARP-1 and the tumor suppressor p53. Heterogeneous nuclear ribonucleoprotein K, residing at the ADF element in association with PARP-1, may serve a platform role in stabilizing the activating complex. PARP-1 coactivated B-Myb- and c-Myb-mediated transactivation of the AR promoter, and p53 antagonized the B-Myb/c-Myb-induced AR promoter activation. PARP-1, heterogeneous nuclear ribonucleoprotein K, B-Myb, and c-Myb each serves as a positive regulator of cellular AR content, whereas p53 negatively regulates AR expression. Our results identify a shared, PARP-1-regulated sensing mechanism that coordinates transcriptional repression of AR during aging and in response to oxidative stress. This study may provide insights as to how advancing age and intracellular redox balance might influence androgen-regulated physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.