ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2008
Increased metabolite concentration in migraine rat model by proton MR spectroscopy in vivo and ex vivo.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Chronic Dysregulation of Cortical and Subcortical Metabolism After Experimental Traumatic Brain Injury.Molecular neurobiology · 2019Article
- Dynamic sodium imaging at ultra-high field reveals progression in a preclinical migraine model.Pain · 2018Article
- Metabolic assessment of a migraine model using relaxation-enhancedMagnetic resonance in medicine · 2018Article
- Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine.Brain research · 2014Article
- (1)H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique.Magma (New York, N.Y.) · 2010Article
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5 authors.
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Abstract
purposeTo investigate brain metabolite change in rat migraine model by proton magnetic resonance spectroscopy (1H-MRS) in vivo and ex vivo.
methods18 Adult SD rats were enrolled in the study. After nitroglycerin administration, the migraine rat model was established according to ethology evaluation. 1H-MRS was performed at 3T MR scanner in vivo and 14.7T Bruker MR spectrometer ex vivo. Area of peak for different metabolite material was obtained and compared by using independent-T test. The significance level was set at p<0.05.
resultsIn thalami of experimental group, areas of peak for Cho, Cr and Glu both in vivo and ex vivo were higher than in control group(p<0.05). In contrast, there was no statistical difference in cerebellum.
conclusionThe elevated Cho and Cr spectral pattern were found in rat migraine model. Neuron activity in thalamus is significantly changeable during attacks.
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